中国临床药理学杂志Issue(4)：324-326,3.DOI:10.13699/j.cnki.1001-6821.2016.04.012
HLA 基因与新疆维吾尔族癫痫患者中拉莫三嗪所致药疹的关联性
Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in the Uyghur population with epilepsy of Xinjiang region
摘要
Abstract
Objective To investigate the relationship between HLA -A*3001 , HLA-A*3101 , HLA-B*1502 , HLA-B*38 , HLA-B*5801 alleles and lamotrigine -induced cutaneous adverse drug reactions in Xinjiang Uyghur epilepsy patients.Methods HLA-A*3001, HLA-A*3101, HLA-B*1502, HLA-B*38, HLA-B*5801 alleles genoty-ping was performed by a polymerase chain reaction -sequence specific primers ( PCR -SSP ) method in 28 subjects who had lamotrigine .10 Uyghur subjects had lamotrigine -induced maculopapular exanthema ( MPE) , 18 lamotrigine tolerant controls ) , and 30 healthy individuals , and the correlation between HLA genes and LTG -MPE was analyzed.Results There seemed to be no statistical differences in the positive frequency of subjects with the HLA -A*3001, HLA -A*3101, HLA-B*1502, HLA -B*38, HLA -B*5801 alleles between the LTG-MPE group and LTG-tolerant group, and normal group (P>0.05). Conclusion There seems to be no significant correlation between HLA -A*3001, HLA-A*3101, HLA-B*1502, HLA-B*38, HLA-B*5801 alleles and lamotrigine induced cutaneous adverse drug reactions .关键词
癫痫/芳香类抗癫痫药物/拉莫三嗪/人类白细胞抗原/斑丘疹Key words
epilepsy/aromatic antiepileptics drugs/lamotrigine/human leucocyte antigen/maculopapular exanthema分类
医药卫生引用本文复制引用
高阳,于爱平,蒋玉凤,于鲁海,赵宗峰,张艳君..HLA 基因与新疆维吾尔族癫痫患者中拉莫三嗪所致药疹的关联性[J].中国临床药理学杂志,2016,(4):324-326,3.基金项目
国家自然科学基金资助项目 （）
