中国临床药理学杂志Issue(4)：351-353,3.DOI:10.13699/j.cnki.1001-6821.2016.04.021
卡泊芬净联合克林霉素治疗重症肺孢子菌肺炎的案例分析
Analysis of caspofungin combined with clindamycin for severe pneumocystis pneumonia
周庆涛 1沈宁 1王蒙 1孙丽娜 1丁艳苓 1贺蓓1
作者信息
- 1. 北京大学第三医院呼吸内科，北京 100191
- 折叠
摘要
Abstract
Objective To investigate the therapeutic value of caspofun-gin combined with clindamycin for pneumocystis pneumonia ( PCP ).Methods The clinical data of two severe PCP patients treated by caspo-fungin combined with clindamycin regimen in department of respiratory medicine of our hospital were analyzed.Because of definitely sulfame-thoxazole/trimethoprim (SMZ/TMP) allergy history, they were both ini-tially treated with caspofungin single drug , and received mechanical ven-tilation and methylprednisolone treatment.However , clindamycin was added to both patients after 3-4 days because of poor response to caspo-fungin monotherapy.Then they got better gradually , the arterial blood gas and chest CT scan showed that the respiratory failure and lung infil-tration were much improved.Results and Conclusion The courses of caspofungin combined with clindamycin were both 3 weeks, the patients were cured without adverse drug reactions.For PCP patients with limited usage of SMZ/TMP, caspofungin combined with clindamycin may be an effective and safe regimen.关键词
肺孢子菌/肺炎/卡泊芬净/克林霉素Key words
pneumocystis/pneumonia/caspofungin/clindamycin分类
医药卫生引用本文复制引用
周庆涛,沈宁,王蒙,孙丽娜,丁艳苓,贺蓓..卡泊芬净联合克林霉素治疗重症肺孢子菌肺炎的案例分析[J].中国临床药理学杂志,2016,(4):351-353,3.
