中国免疫学杂志Issue(2)：226-229,4.DOI:10.3969/j.issn.1000-484X.2016.02.018
类风湿关节炎患者罹患椎体骨折危险的Meta分析
Relationship between rheumatoid arthritis and risk of vertebral fractures
摘要
Abstract
Objective:To summarize the evidence for the link between rheumatoid arthritis and risk of vertebral fractures or vertebral deformities with a meta-analysis, so as to provide objective proof for early preventing and the development of vertebral deformity and fractures.Methods:Wanfang,CNKI,VIP,PUBMED,Springlink and Elsevier were retrieved for all publications relating to rheumatoid arthritis and vertebral fractures in women.According to inclusion and exclusion criteria,two investigators collected their data individually,then statistical analysis was performed using Stata 12.0 software.Results: Eight case-control studies were enrolled, including 86 741 participants,2 258 of them with RA.The results of Meta-analysis showed that a higher incidence of vertebral fractures in RA,and Odds ratio was 3.70 with a 95%confidence interval(2.47-5.55,P<0.000 1).The publication bias analysis did not reveal any evidence of obvious asymmetry, and the sensitivity analysis showed that omission of any individual study made no significant difference for all comparison models,suggesting that our results were statistically robust.Conclusion:RA may be one of the risk factors for the vertebral fractures.关键词
类风湿关节炎/椎体骨折/meta分析Key words
Rheumatoid arthritis/Vertebral fractures/deformities/Meta-analysis分类
医药卫生引用本文复制引用
夏燕,向阳,冯佳,杨年安,陈安平,代玉芳,袁林..类风湿关节炎患者罹患椎体骨折危险的Meta分析[J].中国免疫学杂志,2016,(2):226-229,4.基金项目
本文为国家自然科学基金项目（81360672）和湖北省医学领军人才培养工程专项经费资助。 （）
