中国全科医学Issue(4)：422-426,5.DOI:10.3969/j.issn.1007-9572.2016.04.013
高三酰甘油血症-腰围表型与2型糖尿病患者下肢动脉病变的关系研究
Correlation Between Hypertriglyceridemic - waist Phenotype and Lower Extremity Arterial Diseases in Patients With Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the correlation between hypertriglyceridemic - waist phenotype( HTGW)and lower extremity arterial diseases in patients with type 2 diabetes mellitus(T2DM). Methods From May 2013 to July 2014,we enrolled 404 T2DM patients who were admitted into the Department of Endocrine and Metabolism of the First Affiliated Hospital of China Medical University. According to the condition of high TG level and high WC level,the subjects were divided into 4 groups:TG and WC normal group(group A,n = 65),pure high TG group(group B,n = 19),pure high WC group(group C,n = 103)and HTGW group( group D,n = 217). Comparison was made among the 4 groups in general data and the incidence rate of lower extremity arterial diseases. Independent risk factors for lower extremity arterial diseases were analyzed,and ROC curves were applied to analyze the value of HTGW,WC,WHR and BMI in the diagnosis of lower extremity arterial diseases in male and female patients. Results Group D was higher than group A,group B and group C in the levels of WC,WHR,BMI and Fasting plasma C - peptid,higher than group A and group C in the levels of TC,UA,FINS,2 h C - peptid,and TG,and higher than group A in the level of LDL-C(P < 0. 05);the 4 groups were not significantly different in the levels of 2 hPG, HbA1c ,SBP,DBP,FPG,2 hINS and HDL-C(P > 0. 05). Group D was higher than group A,group B and group C in the incidence rate of lower extremity arterial diseases(P < 0. 05). Multivariate logistic regression analysis showed that age,gender and HTGW were influencing factors for lower extremity arterial diseases in T2DM patients(P < 0. 05). AUC values of HTGW predicting lower extremity arterial diseases in male and female patients were highest,which were 0. 643 and 0. 706 respectively (P < 0. 05);the AUC values of WC and WHR predicting lower extremity arterial diseases in female patients were 0. 647 and 0. 612 respectively(P < 0. 05),while no statistical significance was found in BMI in the diagnosis of lower extremity arterial diseases in male and female patients(P > 0. 05). Conclusion HTGW is correlated with lower extremity arterial diseases and is an independent risk factor for lower extremity arterial diseases. HTGW could be used as a well indicator in the prediction of lower extremity arterial diseases in T2DM patients.关键词
2型糖尿病/高三酰甘油血症 - 腰围表型/下肢动脉病变Key words
Diabetes mellitus,type 2/Hypertriglyceridemic - waist phenotype/Lower extremity arterial diseases分类
医药卫生引用本文复制引用
黄沁,都健..高三酰甘油血症-腰围表型与2型糖尿病患者下肢动脉病变的关系研究[J].中国全科医学,2016,(4):422-426,5.基金项目
辽宁省科学技术厅项目（L2011225020）---脂肪组织内质网应激介导胰岛素抵抗的分子机制及二甲双胍的干预作用；沈阳市科学技术项目（F11-264-1-50）---二甲双胍对胰岛素抵抗大鼠脂肪组织内质网应激干预作用的研究 （）
