中国全科医学Issue(5)：538-541,4.DOI:10.3969/j.issn.1007-9572.2016.05.010
急性呼吸窘迫综合征患者白介素6及白介素8水平变化研究
Changes of the Levels of Interleukin 6 and Interleukin 8 in Patients With Acute Respiratory Distress Syndrome
摘要
Abstract
Objective To investigate the changes of the levels of interleukin 6(IL-6)and interleukin 8(IL-8)in the pathogenetic process of acute respiratory distress syndrome(ARDS). Methods We enrolled 50 ARDS patients who were admitted into the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Xi'an Medical University from December 2010 to February 2013. The patients were divided into cure group(30 patients)and a non - survival group(20 patients). The levels of serum IL-6 and IL-8 were measured on day 1 after admission and right before discharge for cure group and were also measured right before death for non - survival group. We also enrolled 50 healthy subjects as control group,and the levels of serum IL-6 and IL-8 were detected. SPSS 19. 0 statistical software was employed to conduct statistical treatment. Results ARDS group was higher(P ﹤ 0. 01)than control group in the levels of serum IL-6〔(2. 1 ± 1. 8)ng/ L vs. (1. 1 ± 0. 2)ng/L〕and IL-8〔(639. 6 ± 98. 3)ng/ L vs. (415. 9 ± 56. 8) ng/ L〕. Non - survival group was higher(P ﹤ 0. 01)than cure group in the levels of serum IL-6〔(3. 8 ± 0. 2)ng/ L vs. (1. 8 ± 0. 4)ng/ L〕and IL-8〔(687. 8 ± 70. 2)ng/ L vs. (493. 9 ± 71. 7)ng/ L〕,and cure group and non - survival group were all higher(P ﹤ 0. 01) than control group in the two levels. Conclusion The levels of serum IL-6 and IL-8 play an important role in the development of ARDS,and the non - survival group is significantly higher in the level of serum IL-6 and IL-8.关键词
白细胞介素 6/白细胞介素 8/呼吸窘迫综合征,成人Key words
Interleukin - 6/Interleukin - 8/Respiratory distress syndrome,adult分类
医药卫生引用本文复制引用
陈晖,王丹,李亚明,张进召,兀威..急性呼吸窘迫综合征患者白介素6及白介素8水平变化研究[J].中国全科医学,2016,(5):538-541,4.基金项目
西安医学院第一附属医院基金资助项目 （）
