中国全科医学Issue(5)：545-548,4.DOI:10.3969/j.issn.1007-9572.2016.05.012
舒血宁对急性重度一氧化碳中毒患者心型脂肪酸结合蛋白水平的影响
Effect of Shuxuening on Heart - type Fatty Acid Binding Protein of Patients With Acute Severe Carbon Monoxide Poisoning
摘要
Abstract
Objective To study the effect of Shuxuening on heart - type fatty acid binding protein(H-FABP)of the patients with acute severe carbon monoxidepoisoning(ASCOP). Methods We enrolled 138 ASCOP patients who were treated in the emergency department of Harrison International Peace Hospital Affiliated to Hebei Medical University from January 2012 to March 2015. The patients were randomly divided into treatment group( n = 69)and convention group( n = 69). Before treatment(2 hours after poisoning),and after 7 hours and 14 days treatment,troponin I(cTnI),H-FABP,malondialdehyde (MDA)and superoxide dismutase(SOD)of patients were detected. Results The total effective rates of the treatment group and the convention group were 94. 2% (65 / 69)and 69. 6% (48 / 69)respectively;the two groups were significantly different (χ2 = 14. 118,P ﹤ 0. 001). Multiple factor variance analysis showed that the influence of time and grouping on cTnI,H-FABP, MDA and SOD levels of the two groups was significant(P ﹤ 0. 05),and the influence of time and grouping on cTnI,H-FABP, MDA and SOD levles of the two groups interacted with each other( P ﹤ 0. 05). Before treatment,the two groups were not significantly different in cTnI,H-FABP,MDA and SOD levels(P ﹥ 0. 05). After 7 hours treatment,the convention group had higher cTnI and H-FABP levels than treatment group(P ﹤ 0. 05);the two groups both had higher cTnI and H-FABP levels than those before treatment(P ﹤ 0. 05). After 14 days treatment ,the two groups had lower cTnI,H-FABP,MDA and SOD levels than those after 7 h treatment(P ﹤ 0. 05). After 14 days treatment,the convention group was higher than the treatment group in MDA level,lower in SOD level(P ﹤ 0. 05). The disease severity of ASCOP patients had positive correlation with H-FABP level ( rs = 0. 739,P ﹤ 0. 01). Conclusion The early administration of Shuxuening on ASCOP patients,can improve tissue hypoxia, eliminate oxygen free radicals,resist free radical injury,inhibit lipid peroxidation and promote the recovery of organ function.关键词
一氧化碳中毒/脂肪酸转运蛋白质类/舒血宁/治疗Key words
Carbon monoxide poisoning/Fatty acid transport proteins/Shuxuening/Therapy分类
医药卫生引用本文复制引用
李伟,李敬,王霞,李佳,刘晓婷,褚永果,张玮..舒血宁对急性重度一氧化碳中毒患者心型脂肪酸结合蛋白水平的影响[J].中国全科医学,2016,(5):545-548,4.基金项目
河北省衡水市2014科研基金 （）
