中国全科医学Issue(5)：605-610,6.DOI:10.3969/j.issn.1007-9572.2016.05.027
野生型p53诱导的磷酸酶1与肿瘤发生发展及耐药关系的研究进展
Research Progress of the Role of Wild - type p53 - induced Phosphatase in Regulating Tumorigenesis and Drug Resistance
摘要
Abstract
The wild-type p53-induced phosphatase 1(Wip1)is a serine/ threonine phosphatase and belongs to the protein phosphatase type 2C(PP2C)family. Wip1 is an oncogene,and it can promote tumorigenesis through the coordination with other oncogenes and oncogenic signaling pathways and play an important role in the development of tumors. In the article, the mechanism of Wip1 in promoting the development of tumors was discussed from the aspects of the inhibition of DNA damage response,INK4a/ ARF signaling pathway,the regulation of tumor cell invasion, metastasis and apoptosis related protein expression. The related signal transduction molecules involved in the promotion of tumor development by Wip1 were pointed out. And the role of Wip1 in the chemotherapy resistance and radiation resistance of tumor cells was discussed.关键词
Wip1 基因/肿瘤形成过程/基因,p53/DNA 损伤/基因调控网络/抗药性,肿瘤Key words
Wip1 gene/Neoplastic processes/Genes,p53/DNA damage/Gene regulatory networks/Drug resistance,neoplasm分类
医药卫生引用本文复制引用
杨臻,田晓琳,王建英,许亚梅..野生型p53诱导的磷酸酶1与肿瘤发生发展及耐药关系的研究进展[J].中国全科医学,2016,(5):605-610,6.基金项目
北京市自然科学基金资助项目 （）
