中国全科医学Issue(6)：644-647,4.DOI:10.3969/j.issn.1007-9572.2016.06.005
适量饮用白酒对2型糖尿病患者氧化应激和炎症的急性影响
Acute Effects of Moderate Alcohol Intake on Oxidative Stress and Inflammation in Patients With Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the acute effects of moderate alcohol intake on oxidative stress and inflammation in patients with type 2 diabetes mellitus who receive insulin treatment. Methods Enrolled 40 type 2 diabetes mellitus patients who accorded with inclusion and exclusion criteria and were admitted into the Department of Endocrinology of the First Hospital of Nanjing from May 2012 to August 2013. The patients began to receive insulin pump treatment at admission. Equal amount of mineral water and white spirit were drank with dinner at 17:30 respectively on day 1 and day 2 after alcoholic consumption,and MDA and sICAM-1 levels were detected on the next day respectively. Based on the results of continuous glucose monitoring and whether hypoglycemia occurred 24 hours after alcohol intake,the patients were divided into non - hypoglycemia group(n = 25) and hypoglycemia group(n = 15). Results No significant differences were noted between the MDA and sICAM-1 levels after water drinking and those after alcohol drinking(P > 0. 05). The hypoglycemia group was lower than non - hypoglycemia group in MDA level after water drinking(P < 0. 05);there were no significant differences in MDA level after alcohol drinking,sICAM-1 level after water drinking and sICAM-1 level after alcohol drinking between hypoglycemia group and non - hypoglycemia group(P> 0. 05). Non - hypoglycemia group had lower MDA level after alcohol drinking than that after water drinking( P < 0. 05);hypoglycemia group had higher MDA level after alcohol drinking than that after water drinking(P < 0. 05). Conclusion The acute effects of moderate alcohol intake on oxidative stress and inflammation in patients with type 2 diabetes mellitus who receive insulin treatment vary with blood glucose level. Without hypoglycemia,moderate intake of white spirit may counter oxidative stress and inflammation,while patients with hypoglycemia are not recommended to drink alcohol,for even a small amount of alcohol intake could aggregate response to oxidative response.关键词
糖尿病,2 型/饮酒/丙二醛/细胞间黏附分子/炎症Key words
Diabetes mellitus, type 2/Alcohol drinking/Malondial dehyde/Cell adhesion molecules/Inflammation分类
医药卫生引用本文复制引用
金星,陈颖越,马建华,吴锦丹,吴秋霞,蒋兰兰,沈赟,张文礼,罗勇,袁璐,许向红..适量饮用白酒对2型糖尿病患者氧化应激和炎症的急性影响[J].中国全科医学,2016,(6):644-647,4.基金项目
南京市医学科技发展项目 （）
