中国全科医学Issue(6)：693-697,5.DOI:10.3969/j.issn.1007-9572.2016.06.014
加味桂枝茯苓颗粒对大鼠前列腺增生组织血管内皮生长因子和碱性成纤维细胞生长因子表达水平的影响
Influence of Flavored Cassia Twig Tuckahoe Particles on the Expression of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor
摘要
Abstract
Objective To explore the mechanism of flavored cassia twig tuckahoe particles in the treatment of benign prostatic hyperplasia(BPH)by researching the influence of flavored cassia twig tuckahoe particles on the expression of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF). Methods From January 2013 to June 2015,we selected 90 male SD rats. Using random number table method,we divided the rats into normal group(group A,n = 25)and model group(n = 65). After model building,we randomly selected 20 rats from group A and 60 rats from model group. The 60 rats selected from model group were further divided into three groups:control group( group B,n = 20),flavored cassia twig tuckahoe particles group(group C,n = 20)and finasteride group(group D,n = 20)by randorn number table method. The rats of group A were normally fed;group B was given gavage with sodium chloride solution;group C was given gavage with flavored cassia twig tuckahoe particle solution;group D was given gavage with finasteride solution. Twenty - four hours after last gavage, prostate tissues were sampled,and we recorded the prostate volume and prostate hyperplasia index of each group;the expression levels of VEGF and bFGF were detected by immunohistochemical SP method. Results Group B was higher than group A in prostate volume and prostate hyperplasia index(P < 0. 05);group C and group D were lower than group B in prostate volume and prostate hyperplasia index(P < 0. 05). Group B,group C and group D were higher than group A in the levels of VEGF and bFGF(P < 0. 05);group C and group D were lower than group B in the levels of VEGF and bFGF(P < 0. 05). Conclusion Flavored cassia twig tuckahoe particles can lessen prostate volume and prostate hyperplasia index by reducing the levels of VEGF and bFGF in the hyperplasia of prostate gland tissue of rats,thus achieving efficacy in BPH treatment.关键词
前列腺增生/加味桂枝茯苓颗粒/非那雄胺/血管内皮生长因子 A/成纤维细胞生长因子2Key words
Prostatic hyperplasia/Flavored cassia twig tuckahoe particles/Finasteride/Vascular endothelial growth factor A/Fibroblast growth factor 2分类
医药卫生引用本文复制引用
李峰,伍松合,郑仿,闫家文,赵书晓,黄新,马林枫,郑艺,钟新兰,赵军辉..加味桂枝茯苓颗粒对大鼠前列腺增生组织血管内皮生长因子和碱性成纤维细胞生长因子表达水平的影响[J].中国全科医学,2016,(6):693-697,5.基金项目
国家自然科学基金资助项目 （）
