摘要
Abstract
Objective To investigate the clinical manifestations,laboratory inspection,pathological characteristics, treatment and outcome. Methods Enrolled 20 subjects with arsenical keratosis who were admitted into Tianjin Third Central Hospital from March 2010 to January 2015. A retrospective analysis was made on their clinical manifestations,laboratory examination,pathological characteristic,treatment and outcome. Results Among the 20 patients,14 had hyperkeratosis of palms and soles;12 had disperse punctiform,verrucous,cutaneous horn alike and keratinized patch skin lesions on four limbs;6 patients had Bowen disease;6 patients had squamous cell carcinoma;2 patients had recurrent refractory skin ulcer;11 patients had verrucous hyperplasia;8 patients saw skin color deepen all over the body;6 patients saw the color of their nails change with white cross grain on the nails of several patients;6 patients had pruritus and needling - like pain;3 patients had ulceration in oral cavity;4 patients had symptoms of other body systems;18 patients had elevated blood arsenic and urine arsenic levels;3 patients saw blood platelet count decrease;2 patients had elevated creatinine level;diversified changes were found by histopathological examination;sodium dimercaptosulphonate and acitretin were effective,and patients who were complicated with Bowen disease and squamous - cell carcinoma and underwent Mohs′ microsurgical treatment had low recurrence rate. Conclusion Patients with arsenical keratosis are rare and causes are various. Patients have diverse skin lesion characteristics and skin clinical symptoms. Laboratory examination had specificity,and the diagnosis mainly relies on consultation of medical history, clinical manifestations and laboratory examination. Prognosis of patients receiving both drug therapy and surgery is better.关键词
砷中毒/皮肤角化病,掌跖/病理状态,体征和症状Key words
Arsenic poisoning/Keratoderma,palmoplantar/Pathological conditions,signs and symptoms分类
医药卫生
