中国现代医学杂志Issue(2)：13-18,6.DOI:10.3969/j.issn.1005-8982.2016.02.003
人类免疫缺陷病毒,艾滋病病毒1型艾滋病患者CD4+T淋巴细胞水平与机会感染及病毒载量的相关性分析
Correlation of CD4+T lymphocyte level with opportunistic infections and viral load in AIDS patients infected with HIV-1
李铃 1古雪 1敬雨佳 1李芸 2梅小平1
作者信息
- 1. 川北医学院附属医院 感染科，四川 南充 637000
- 2. 四川大学华西医院，四川 成都 610041
- 折叠
摘要
Abstract
Objective To analyze the correlation of CD4+T cell level with HIV load and opportunistic infections in AIDS patients with type 1 human immunodeficiency virus (HIV-1). Methods The plasma load of HIV-1 RNA was detected using real-time PCR OBASAmpliPrep/COBAS TaqMan automatic viral load meter (Roche), and CD4+ T lymphocytes were counted by flow cytometry (FACSCOUNT) absolute counting method for 95 patients with AIDS of HIV-1 infection. Results The majority of the patients with HIV-1 type AIDS were mainly married male farmers with low education level at the age of 35-50 years. They got the infection mainly through sexual transmission. Opportunis-tic infections most commonly occurred in the respiratory system (90 times, 51.5%) and bacterial pneumonia account-ed for the highest incidence (48 times, 27.4%). Based on CD4+T lymphocyte count level the opportunistic infections were divided into 5 groups. Bacterial pneumonia, Pneumoaystis carrii pneumonia, pulmonary tuberculosis, oral Candi-da infection, cryptococcal meningitis, infectious diarrhea and herpes simplex were significantly different among the 5 groups ( < 0.05). When CD4+T cell count was less than 200/μl, the incidence of opportunistic infections was 97.7%. Among the AIDS patients with virus load < 103 copies/ml, most of the individuals had CD4 + T cell count of 200-399/μl (75%);while the virus load≥105 copies/ml, most of the patients had CD4+T cell count<200/μl (45 cases, 73.8%). CD4+T lymphocyte count and viral load were in a negative correlation ( = -0.34, < 0.01). Conclusions The incidence of opportunistic infection is high in AIDS patients. As the viral load increases, CD4+T lymphocyte count declines to various degree. CD4+T cell count is the independent risk factor for opportunistic infec-tion in AIDS patients. Close monitoring CD4+T cell count in ADIS patients is an important means of predicting op-portunistic infections.关键词
艾滋病/机会性感染/CD4+T淋巴细胞/艾滋病病毒- 1/病毒载量Key words
AIDS/opportunistic infection/CD4+T cell/HIV-1/viral load分类
医药卫生引用本文复制引用
李铃,古雪,敬雨佳,李芸,梅小平..人类免疫缺陷病毒,艾滋病病毒1型艾滋病患者CD4+T淋巴细胞水平与机会感染及病毒载量的相关性分析[J].中国现代医学杂志,2016,(2):13-18,6.
