中国现代医学杂志Issue(2)：24-28,5.DOI:10.3969/j.issn.1005-8982.2016.02.005
细胞毒性T淋巴细胞相关抗原4基因多态性与肝癌的易感性研究
Association of CTLA4 polymorphysims with susceptibility to hepatocellular carcinoma
崔伟丽 1李娜 2于君 3亓玉琴 4崔京远5
作者信息
- 1. 山东省青岛市传染病医院肝病五区，山东 青岛 266033
- 2. 山东省青岛市传染病医院肝病六区，山东 青岛 266033
- 3. 山东省青岛市传染病医院肝病九区，山东 青岛 266033
- 4. 山东省青岛市市立医院 消化内一科，山东 青岛 266011
- 5. 山东省青岛市市立医院 普外科，山东 青岛 266011
- 折叠
摘要
Abstract
Objective To explore the correlation between several single-nucleotide polymorphism (SNP) loci on CTLA4 gene and the susceptibility to hepatocellular carcinoma in Qingdao area. Methods This case-control study included 98 patients diagnosed as hepatocellular carcinoma, 185 case with chronic hepatitis B and 205 healthy people. PCR-RFLP was used to study the genotype distribution of CTLA4 gene. Results The genotype frequency of CTLA4+49 and -1661 loci showed significant difference between the hepatocellular carcinoma patients and the healthy people ( <0.05). The frequency of distribution of CTLA4-1722 locus had no significant difference between the hepatocellular carcinoma patients and the healthy people (P>0.05). The additive odds ratio (OR) of genotypes AG and GG in+49 locus and genotype AG+GG in CTLA4-1661 locus for the risk of hepatocellular carcinoma was 2.48, 5.22 and 2.51 respectively. The frequency of genotypes AG and GG in+49 locus and genotype AG+GG in-1661 locus was higher in the hepatocellular carcinoma patients than in the chronic hepatitis B patients ( OR = 2.48, 4.60 and 2.13 respectively). The frequency of genotypes AG and GG in+49 locus and genotype AG+GG in CTLA4-1661 locus was higher in the hepatocellular carcinoma patients than in the non-HCC people (OR =2.48, 4.91 and 2.32 respectively). Conclusions The single-nucleotide polymorphisms on+49-1661 loci may play a landmark role in susceptibility to hepatocellular carcinoma.关键词
细胞毒性T淋巴细胞相关抗原4/单核苷酸多态性/肝癌/HBV感染Key words
cytotoxic T lymphocyte-associated antigen 4/single nucleotide polymorphism/hepatocellular carcinoma/hepatitis B virus infection分类
医药卫生引用本文复制引用
崔伟丽,李娜,于君,亓玉琴,崔京远..细胞毒性T淋巴细胞相关抗原4基因多态性与肝癌的易感性研究[J].中国现代医学杂志,2016,(2):24-28,5.
