中国现代医学杂志Issue(2)：33-37,5.DOI:10.3969/j.issn.1005-8982.2016.02.007
p-Akt在预测乳腺癌术后转移复发中的临床意义
Clinical significance of p-Akt in predicting metastasis of breast cancer after surgery
刘冬良 1杭振宁 1顾汝军1
作者信息
- 1. 解放军第82医院149临床部 外二科，江苏 连云港 222042
- 折叠
摘要
Abstract
Objective To study the clinical significance of p-Akt in predicting the metastasis of breast cancer after surgery. Methods A total of 261 patients who were admitted into our hospital after breast cancer surgery from January 2001 to March 2010 were studied. There were 114 patients in metastasis group and 147 patients in non-metastasis group. The expression of p-Akt in the breast cancer patients with or without metastasis after surgery was detected by immunohistochemistry and the correlation between the expression of p-Akt and breast cancer metastasis was analyzed. Results There was significant difference in p-Akt expression between normal breast tissue and breast cancer tissues ( <0.05). The p-Akt expression of breast cancer tissues also had significant difference between the metastasis group and non-metastasis group ( <0.05). The abnormal p-Akt expression was significantly associated with the tumor size, regional lymph node metastasis and TNM staging of the patients with breast cancer ( <0.05). Univariate logistic regression analysis showed that abnormal expression of p-Akt was correlated with the metastasis of breast cancer after surgery ( =0.043, RR=1.638, 95%Cl: 1.337-1.955). Conclusions The abnormal expression of p-Akt may be associated with the metastasis of breast cancer after surgery.关键词
p- Akt/乳腺癌/转移复发/预后Key words
p-Akt/breast cancer/metastasis/prognosis分类
医药卫生引用本文复制引用
刘冬良,杭振宁,顾汝军..p-Akt在预测乳腺癌术后转移复发中的临床意义[J].中国现代医学杂志,2016,(2):33-37,5.
