摘要
Abstract
Objective To investigate the effect of thyroid-stimulating hormone (TSH) suppressive therapy on bone mineral density (BMD) and blood biochemical indexes in patients with differentiated thyroid carcino-ma (DTC) who had received 131I after surgery. Methods This study recruited 44 patients with DTC who had received 131I ablation therapy and were taking LT4 after surgery (TSH < 0.1 mU/L). After 6 month of ablation therapy, these patients would be hospitalized again to assess whether therapy was successful or the removal of metastases was needed. The patients' blood biochemical indexes were analyzed when they were hospitalized at the first time and the second time. Those blood biochemical indexes included GPT, GOT, AKP, GLU, BUN,Cr, Ca, P, TC, TG, HDL, LDL, CT, BGP and PTH. Besides, the indexes including the BMD of L1-L4, Neck, greater Troch and Ward's triangle were analyzed. The differences in the values were expressed as △. For ex-ample, △GPT =GPT1-GPT2. Results A negative correlation was found between age and Ward1, and the nega-tive correlations of age with Neck2 and Ward2 were more obvious. The multiple regression equation also sup-ported those results (Ward2=1.001-0.008 year). Age was positively correlated to △Ward. The postoperative time interval (at average of 60.5 days) was negatively correlated to △BGP and had no significant correlation with BMD of any part. The TSH suppression time was negatively correlated to BGP2 and positively correlated to Neck2. Conclusions The combination of 131I and TSH suppressive therapy has little influence on BMD in a duration of 6 months. Age is negatively correlated to Ward. The older the patients, the lower the Ward and the larger the △Ward. Neither postoperative time interval nor TSH suppression time has significant effect on BMD.关键词
131I/TSH抑制治疗/分化型甲状腺癌/血生化/骨密度Key words
131I/TSH suppressive therapy/DTC/blood biochemical index/BMD分类
医药卫生
