中国现代医学杂志Issue(2)：134-138,5.DOI:10.3969/j.issn.1005-8982.2016.02.031
依那普利叶酸片对中青年H型高血压患者血压和血压变异性的影响*
Effect of Enalapril-folic aicd on blood pressure and its variability in young and middle-aged patients with H-type hypertension
摘要
Abstract
Objective To investigate effect of Enalapril-folic aicd on blood pressure and blood pressure variability in young and middle-aged patients with H-type hypertension. Methods A total of 102 young and middle-aged cases with untreated essential H-type hypertension were chosen. They were randomly divided into control group treated with Enalapril alone (50 cases) and experimental group treated with Enalapril-folic acid (52 cases). All were followed up for 24 weeks. Twenty-four hour ambulatory blood pressure monitoring method was used to determine the average systolic blood pressure and diastolic blood pressure of 24 hours, standard deviation of 24-hour systolic blood pressure and 24-hour diastolic blood pressure, standard deviation of diur-nal systolic blood pressure and diastolic blood pressure and standard deviation of nocturnal systolicl blood pressure and nocturnal diastolic blood pressure before treatment and 24 weeks after treatment. Plasma level of homocysteine was detected before treatment and 24 weeks after treatment. Results In the experimental group, plasma level of homocysteine, standard deviation of 24-hour systolic blood pressure, daytime systolic blood pressure and nighttime systolicl blood pressure significantly decreased ( <0.05) compared with those before treatment. The experimental group's standard deviation of 24-hour diastolic blood pressure, daytime diastolic blood pressure and nighttime diastolic blood pressure decreased slightly compared with those before treatment;but there were no significant differences ( >0.05). Plasma level of homocysteine, standard deviation of 24-hour systolic blood pressure, daytime systolic blood pressure, nighttime systolicl blood pressure, 24-hour dias-tolic blood pressure, daytime diastolic blood pressure and nighttime diastolic blood pressure decreased slightly after treatment in the control group; but there were no significant differences ( >0.05). In the experimental group and the control group 24-hour average systolic blood pressure and 24-hour average diastolic blood pressure significantly lowered compared to those before treatment ( <0.001). But the difference in the anti-hypertensive effect was not statistically significant between both groups ( >0.05). Conclusions Blood pressure can be effectively lowered by both Enalapril and Enalapril-folic aicd in young and middle-aged patients with H-type hypertension. Systolic blood pressure variability and homocysteine level are obviously reduced by Enalapril-folic aicd in the patients.关键词
依那普利叶酸片/H型高血压/血压变异性Key words
Enalapril-folic acid/H-type hypertension/blood pressure variability分类
医药卫生引用本文复制引用
伍先亮,傅广,马丽霞,冯荣,汤华,廖春锋,黄树斌,石顺华..依那普利叶酸片对中青年H型高血压患者血压和血压变异性的影响*[J].中国现代医学杂志,2016,(2):134-138,5.基金项目
长沙市科技局课题 （）
