中国现代医学杂志Issue(3)：14-17,4.DOI:10.3969/j.issn.1005-8982.2016.03.003
先天性马蹄内翻足与基因家族的相关性研究*
Association between idiopathic congenital talipes equinovarus and gene family
摘要
Abstract
Objective To study the association between idiopathic congenital talipe equinovarus (ICTEV) and gene family (FoxO1,FoxO3 and FoxO4 ). Methods A total of 80 ICTEV patients and 40 normal controls were collected in the Affiliated Hospital of Xinjiang Medical University between 2012 and 2014. The RT-PCR and Western blot were performed to evaluate the levels of mRNA and protein of , and from ICTEV patients and normal controls. Results Compared with the normal controls, the ICTEV pa-tients showed down-regulation of gene in transcription (P=0.021). However there was no difference in or (P=0.738). Western blot showed that FoxO1 protein was down-regulated in muscular tissue of the ICTEV patients (P= 0.017), neither FoxO3 nor FoxO4 protein level had significant difference (P=0.672). Compared with the Han ICTEV patients, the Uygur ICTEV patients showed down-regulation of gene in transcription ( P<0.05), but there was no difference in or (P>0.05). Conclusions There is a significant correlation between ICTEV and gene family. The low expression level of could lead to the occurrence of ICTEV. In addition, these results indicated that the Uygur ICTEV patients are prone to be influenced by the expression level of .关键词
先天性马蹄内翻足/基因家族/表达水平Key words
idiopathic congenital talipes equinovarus/gene family/expression level分类
医药卫生引用本文复制引用
程国杰,艾克巴尔·阿不都热西提,王晶,王磊..先天性马蹄内翻足与基因家族的相关性研究*[J].中国现代医学杂志,2016,(3):14-17,4.基金项目
国家自然科学基金 （）
