中国现代医学杂志Issue(3)：18-22,5.DOI:10.3969/j.issn.1005-8982.2016.03.004
程序性细胞死亡4 mRNA在结直肠癌组织中的表达及意义*
Expression of mRNA in human colorectal cancer and its significance
摘要
Abstract
Abastract: Objective To study programmed cell death 4 (PDCD4) mRNA expression in colorectal cancer tissues from laparoscopic radical resection, as well as its relationship with the clinical data of colorectal cancer. Methods Specimens of colorectal cancer tissues and normal tissues adjacent to carcinoma from 54 cases were collected in laparoscopic surgery between 2012 and 2014. mRNA level was detected by RT-PCR in colorectal cancer specimens. The relationship between mRNA level and clinical data was analyzed. Results expression in the colorectal cancer tissues reduced or even was not seen, the rate of lowered expression was 64.8% (35/54) with ∆Ct (4.50 ± 0.60); the normal tissues had high expression of with 吟Ct (3.54±0.52), the difference was statistically significant ( <0.05). The mRNA level in the colorectal cancer tissues was correlated with the differentiation degree, lymph node metastasis and tumor infiltration depth, but not correlated with gender, age or tumor location. mRNA expression was lower in patients with lymph node metastases than those without ymph node metastasis. The lower the degree of differentiation and the deeper infiltration, the lower the mRNA expression. Conclusions mRNA expression lowers in colorectal cancers. mRNA level is not correlated with gender, age or tumor location, but correlated with degree of differentiation, lymph node metastasis and tumor infiltration depth.关键词
腹腔镜/结直肠癌/程序性细胞死亡4Key words
laparoscope/colorectal cancer/programmed cell death 4分类
医药卫生引用本文复制引用
李日恒,李爽,宋艳敏,张爱民,刘渤,胡光..程序性细胞死亡4 mRNA在结直肠癌组织中的表达及意义*[J].中国现代医学杂志,2016,(3):18-22,5.基金项目
河北省科技计划项目 （）
