中国现代医学杂志Issue(3)：27-33,7.DOI:10.3969/j.issn.1005-8982.2016.03.006
C型CD133和缺氧诱导因子-1α在胃癌组织中的表达及其预后价值
Expression of CD133 and hypoxia inducible factor-1αin gastric cancer and clinical significance
何志国 1李盆洲 1朱晒红1
作者信息
- 1. 中南大学湘雅三医院 普外科，湖南 长沙 410003
- 折叠
摘要
Abstract
Objective To clarify the clinical role of CD133 expression in gastric cancer and to investigate the correlation between CD133 expression and hypoxia inducible factor (HIF)-1α expression. Methods Totally 189 gastric cancer patients who underwent gastrectomy in the Fourth Hospital of Changsha City were studied. CD133 and HIF-1α expressions were examined using immunohistochemical staining. Fifty-six cases were CD133-positive, and they were divided into two expression types: luminal expression of the gland and cyto-plasmic expression. The clinicopathological variables, prognosis and HIF-1a expression were compared among the three groups of different CD133-expression types. Results The expression of CD133 in the cytoplasm was correlated to metastasis and tumor progression. However, this relationship was not observed with luminal ex-pression type of the gland. The survival rate in the patients with cytoplasmic CD133 expression was signifi-cantly lower than that in the CD133-negative group. The same relationship was observed in the survival rate of the adjuvant chemotherapy group and the curative resection group. Multivariate analysis revealed that the expression of CD133 in the cytoplasm was an independent prognostic factor for gastric cancer. HIF-1α posi-tive rate was higher in the patients with cytoplasmic CD133 expression than in those with luminal CD133 expression. Conclusions Gastric cancer cells with CD133 expression in the cytoplasm have high potential for malignancy, and this phenotype is associated with cancer progression, chemotherapy resistance, recurrence and poor prognosis. Cytoplasmic expression of CD133 may be a useful prognostic marker for gastric cancer. A sig-nificant correlation is observed between HIF-1α expression and the immunohistochemical staining pattern of CD133.关键词
胃癌/CD133/预后/缺氧诱导因子- 1αKey words
gastric cancer/CD133/prognosis/hypoxia inducible factor-1α分类
医药卫生引用本文复制引用
何志国,李盆洲,朱晒红..C型CD133和缺氧诱导因子-1α在胃癌组织中的表达及其预后价值[J].中国现代医学杂志,2016,(3):27-33,7.
