中国现代医学杂志Issue(3)：34-38,5.DOI:10.3969/j.issn.1005-8982.2016.03.007
晚期非小细胞肺癌中上皮细胞间质转型和表皮生长因子受体的检测及其相关性研究
Relationship between EGFR and EMT in advanced non-small cell lung cancer
柴春香 1王晓敏 2郭文君 2孙永红2
作者信息
- 1. 潍坊医学院附属医院医务科，山东 潍坊 261000
- 2. 潍坊医学院附属医院病理科，山东 潍坊 261000
- 折叠
摘要
Abstract
Objective To investigate the relationship of epithelial-mesenchymal transition (EMT) and epi-dermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC). Methods Immunohistochemistry (EnVision method) was used to detect the expressions of EGFR, E-cadherin and vimentin. Exons 18-21 of were detected by PCR and gene sequencing. Results The positive expression rate of EGFR, E-cad-herin and vimentin was 61.5%(48/78), 43.6%(34/78), 56.4%(44/78) respectively in the 78 cases of NSCLC;while they were not expressed in the normal group. The mutation rate of gene was 24.4% (19/78) in the NSCLC group. The incidence of EMT was higher in the wild-type group than in the mutation group (67.8% vs 21.1%). There was a positive correlation between EGFR protein expression and EMT ( =0.236,=0.037). Conclusions Lost E-cadherin and EGFR signaling pathways could promote the formation of EMT.关键词
晚期非小细胞肺癌/上皮细胞间质转型/表皮生长因子受体Key words
non-small cell lung cancer/epithelial-mesenchymal transition/epidermal growth factor receptor分类
医药卫生引用本文复制引用
柴春香,王晓敏,郭文君,孙永红..晚期非小细胞肺癌中上皮细胞间质转型和表皮生长因子受体的检测及其相关性研究[J].中国现代医学杂志,2016,(3):34-38,5.
