中国现代医学杂志Issue(3)：45-49,5.DOI:10.3969/j.issn.1005-8982.2016.03.009
2型糖尿病男性患者血清羧化不全骨钙素水平与其认知功能受损的相关性研究*
Association of serum undercarboxylated osteocalcin with cognitive deficits in male T2DM patients
摘要
Abstract
Objective To investigate the association of serum undercarboxylated osteocalcin (ucOC) with cognitive deficits in male T2DM patients. Methods Seventy-one male inpatients in Tangshan Gongren Hospital and 68 male controls without T2DM from the Medical Examination Center were recruited. Data on demographic characteristics (including age, education, duration of illness and BMI) and clinical parameters (including FPG, HbA1c, TC, TG, LDL and HDL) were collected. ELISA was used to measure ucOC. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), which consists of five subtests including immediate memory, visuospatial/constructional, language, attention and de-layed memory. The scores from the aboved five subtests were scaled together to create a total score. Diffe-rences in RBANS scores were compared between the T2DM group and the control group. The T2DM patients were further divided into two groups according to the average level of ucOC, and the differences in RBANS scores were compared between the two groups. The correlation of osteocalcin with RBANS scores was ana-lyzed. Results Serum TC, TG and FPG were all higher ( <0.05), and HDL and ucOC were lower ( <0.05) in the T2DM patients than those in the controls. Age, education, BMI and serum LDL were similar in both groups ( >0.05). The total RBANS score and the subtest scores except for that of language were lower in the T2DM patients than in the controls ( <0.05). In the T2DM group, immediate memory, language, attention, delayed memory and total scores of the patients with ucOC-H were all higher than those of the patients with ucOC-L ( <0.05). Stepwise regression analysis showed that for the T2DM patients, ucOC was inversely corre-lated with HbA1c ( <0.001), but was postively correlated with immediate memory, language, attention and delayed memory scores and total RBANS score ( <0.05). Conclusions Decreased serum ucOC level may be one of the risk factors for cognitive deficits in male T2DM patients.关键词
2型糖尿病/男性/羧化不全骨钙素/认知Key words
T2DM/male/undercarboxylated osteocalcin/cognition分类
医药卫生引用本文复制引用
孙雪玲,房辉,李玉凯,张禾伟,安彩霞,杨岳,甄艳凤,张谷月,张丹丹..2型糖尿病男性患者血清羧化不全骨钙素水平与其认知功能受损的相关性研究*[J].中国现代医学杂志,2016,(3):45-49,5.基金项目
河北省自然科学基金 （）
