中国现代医学杂志Issue(3)：120-125,6.DOI:10.3969/j.issn.1005-8982.2016.03.025
多种过继性细胞免疫联合替吉奥治疗老年晚期胃癌患者的临床研究
Multicellular adoptive immunotherapy combined with S-1 in the elderly patients with advanced gastric cancer
张晓蕾 1魏玮 1杨春梅 1刘曰芬 1郭海生 1王旬果1
作者信息
- 1. 山东省东营市人民医院 肿瘤科，山东 东营 257000
- 折叠
摘要
Abstract
Objective To explore the recent treatment effect and toxicity of multicellular adoptive immunotherapy combined with S-1 in the elderly advanced gastric cancer patients, and compare the difference in the therapeutic effect between multicellular adoptive immunotherapy combined with S-1 and S-1 used alone. Methods Thirty-two elderly patients who were diagnosed as advanced gastric cancer in our hospital were selected. The patients were randomly divided into two groups. The combined treatment group used multicellular adoptive immunotherapy combined with S-1, while the control group used S-1 alone. The clinical therapeutic effect was observed through imaging and laboratory results. The median progression-free survival (PFS), the patients' quality of life, the toxicity and immunity were observed. Results The median progression-free survival in the combined treatment group and the control group was 4.7 months and 3.9 months respectively, the difference was statistically significant ( < 0.05). Multicellular adoptive immunotherapy in combination with S-1 therapy significantly improved the patients' quality of life, especially for insomnia, fatigue and stomachic effect. Comaring the adverse reactions of both groups, the combined treatment group only had additional fever with lower incidence. The combined treatment had high safety compared to S-1 alone. Conclusions Compared with the therapy of S-1 alone, multicellular adoptive immunotherapy combined with S-1 has significant efficacy and low toxicity for the treatment of advanced gastric cancer in elderly patients, can prolong their progression-free survival, and improve the patients' quality of life and immunity.关键词
过继性细胞免疫治疗/替吉奥胶囊/晚期胃癌/生活质量/免疫功能Key words
adoptive cellular immunotherapy/S- 1 capsule/advanced gastric cancer/quality of life/immunity分类
医药卫生引用本文复制引用
张晓蕾,魏玮,杨春梅,刘曰芬,郭海生,王旬果..多种过继性细胞免疫联合替吉奥治疗老年晚期胃癌患者的临床研究[J].中国现代医学杂志,2016,(3):120-125,6.
