中国医学创新Issue(35)：132-134,3.DOI:10.3969/j.issn.1674-4985.2015.35.044
齐拉西酮联合小剂量氯氮平对改善难治性精神分裂症症状及安全性分析
Ziprasidone Combined with Small Dose of Clozapine on the Improvement of the Symptoms of Refractory ;Schizophrenia and Safety Analysis
摘要
Abstract
Objective:To investigate the improvement effect of Ziprasidone combined with small dose of Clozapine in the symptoms of refractory schizophrenia and its safety.Method:80 patients with refractory schizophrenia admitted to our hospital from January 2013 to December 2014 were selected and divided into the control group and the research group according to the random number table method,40 cases in each group.The control group was treated with Clozapine,the rearch group was given Ziprasidone combined with Clozapine for treatment.The improvement of disease symptoms and adverse reactions between the two groups were compared,and they were evaluated the positive and negative symptom scale(PANSS)and the side reaction scale(TESS)8 weeks after administration.Result:After 8 weeks,the PANSS total score,positive symptoms and negative symptoms score of the two groups after treatment were significantly lower than before treatment,and those of the research group were significantly lower than the control group,the differences were statistically significant(P<0.05).The total effective rate of the research group was 87.5%,which was significantly higher than 67.5%of the control group,the difference was statistically significant(χ2=4.588,P=0.032).The incidence of constipation,drowsiness,orthostatic hypotension,ECG abnormal phenomenon and the increase of body mass in the research group were significantly lower than those in the control group,the differences were statistically significant(P<0.05). Conclusion:Ziprasidone combined with small dose of Clozapine can significantly improve the symptoms of refractory schizophrenia,reduce the incidence of adverse reactions,improve the clinical safety,is worthy of clinical promotion.关键词
难治性精神分裂症/氯氮平/齐拉西酮/PANSS/TESSKey words
Refractory schizophrenia/Ziprasidone/Clozapine/PANSS/TESS引用本文复制引用
孔令军,左小云,周永彬,焦峰..齐拉西酮联合小剂量氯氮平对改善难治性精神分裂症症状及安全性分析[J].中国医学创新,2015,(35):132-134,3.基金项目
2012年江西省卫生厅科研计划（普通）课题 （）
