中国医学创新Issue(36)：48-50,3.DOI:10.3969/j.issn.1674-4985.2015.36.016
中国东北人群中转化生长因子-α基因rs3771494单核苷酸多态性与非综合征唇腭裂的关系
Association of Single Nucleotide Polymorphism of rs3771494 in TGF-α Gene and Nonsyndromic Cleft Lip with or without Cleft Palate in Northeast China People
摘要
Abstract
Objective:To investigate the relationship between single nucleotide polymorphism(SNP) of rs3771494 in transforming growth factor-α(TGF-α) gene and nonsyndromic cleft lip with or without cleft palate(NSCL/P) in northeast Chinese populations.Method:236 cases of NSCL/P and 400 health volunteers from northeast China were collected,the former were as the disease group and the latter were as the control group.The genotypes were detected by gene microarray,the genotypes were analyzed and compared between the two groups.Result:The frequencies of genotypes TC,CC and TC+CC in the disease group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The genotypes TC and CC at rs3771494 in TGF-α gene are related to the morbidity of NSCL/P in northeast Chinese populations.关键词
转化生长因子-α/非综合征唇腭裂/多态性/基因芯片Key words
Transforming growth factor-α/Nonsyndromic cleft lip with or without cleft palate/Polymorphisms/Gene microarray引用本文复制引用
胥威,卢永平,韩维田,宋方田..中国东北人群中转化生长因子-α基因rs3771494单核苷酸多态性与非综合征唇腭裂的关系[J].中国医学创新,2015,(36):48-50,3.基金项目
辽宁省科技攻关项目 （）
