摘要
Abstract
Objective:To explore the changes of transcranial Doppler(TCD) and its clinical significance in recombinant tissue plasminogen activator(r-tPA) thrombolytic therapy of patients with cerebral infarction.Method:76 cerebral infarction patients who met the standard of thrombolytic in our hospital from May 2014 to November 2014 were selected,and were randomly divided into the observation group and the control group according to whether the application of TCD monitoring,38 cases in each group.The observation group was treated with r-tPA combined with TCD,and the control group was treated with r-tPA.The revascularization and intracranial hemorrhage between the two groups were detected,and the NIHSS score and Barthel index between the two groups in different time periods were determined,the complications after treatment between the two groups were observed.Result:The revascularization rate of the observation group was 76.32%,which was significantly higher than 44.74% of the control group,the difference was statistically significant(P<0.05),there was no statistically significant difference in intracranial hemorrhage rate between the two groups(P>0.05).The NIHSS score of the observation group 7 days and 3 weeks after treatment were significantly lower than those of the control group, the Barthel index of the observation group 1 month and 3 months after treatment were significantly higher than those of the control group,the total complication rate of the observation group was 5.26%,which was significantly lower than 21.05% of the control group,the differences were statistically significant(P<0.05). Conclusion:TCD in cerebral infarction patients r-tPA thrombolytic therapy has good synergistic effect,not only can increase the recanalization rate,reduce the intracranial hemorrhage,but also has significant effect in the improvement of patients with neurological function recovery,is worthy of clinical promotion.关键词
脑梗死/溶栓/重组组织型纤溶酶原激活剂/经颅多普勒Key words
Cerebral infarction/Thrombolytic/Recombinant tissue plasminogen activator/TCD
