中国医学创新Issue(2)：111-114,4.DOI:10.3969/j.issn.1674-4985.2016.02.031
丙泊酚注射液与依托咪酯脂肪乳注射液的配伍稳定性研究
Study on the Compatible Stability of Propofol Injection and Etomidate Fat Emulsion Injection
摘要
Abstract
Objective:To investigate and analyze the compatible stability of the injection mixture composed of Propofol and Etomidate fat emulsion,to provide a experimental basis for clinical use.Method:The same experiment group who used the same pipette to take Propofol injection and Etomidate injection.The mixture with volume ratio of Propofol injection to Etomidate fat emulsion injection equaling 1∶1,was stored for 0,1,3,5, 7,9 h and 10 h at 25 ℃,and its emulsion particle size distribution,ζ potential and pH value at different time points were measured.The content of two kinds of drugs were determined using high performance liquid chromatography method.The areas of one-dimensional H1-NMR peaks of proton para to the phenolic hydroxyl group of Propofol(4-H), and proton bonding to the C atom between the two N atoms of Etomidate(5-H) at the above time points were detected using nuclear magnetic resonance spectroscopy(NMR) method.Result:The pH values of the compatible solution at different times were (7.60±0.41),(7.50±0.39),(7.55±0.40),(7.62±0.43),(7.64±0.42), (7.58±0.40),(7.59±0.40),which showed no significant differences between any two different time points (P>0.05).Similarly,the emulsion particle size distribution and ζ potential of the compatible solution at different time points showed no significant differences (P>0.05).Calculation on drug content of 0 h was 100%,the contents of Propofol of compatible solution were(99.80±1.20),(98.80±1.18),(99.40±1.16),(98.40±1.20), (98.50±1.15),(98.80±1.22)%,which showed no significant differences between any two different time points (P>0.05).Also the content of Etomidate of compatible solution showed no significant differences between any two samples at different time points(P>0.05).5-H and 4-H peak areas of Propofol and Etomidate of compatible solution at different time points respectively fluctuated within the range of(53 025 430.60±58 943.70), (16 342 703.21±3785.60),there showed no significant differences between any two different time points (P>0.05).Conclusion:In the compatible solution composed of Propofol injection and Etomidate fat emulsion injection with volume ratio of 1∶1,the emulsion particle size distribution,ζ potential,pH value,the content of the two drugs,as well as the H1-NMR peak areas of 4-H of Propofol and 5-H peak of Etomidate are not change significantly,it indicates that the compatible solution is stable in 10 h at room temperature.关键词
丙泊酚注射液/依托咪酯脂肪乳注射液/配伍/稳定性Key words
Propofol injection/Etomidate fat emulsion injection/Compatible/Stability引用本文复制引用
白瑶,洪飚,刘玉琴..丙泊酚注射液与依托咪酯脂肪乳注射液的配伍稳定性研究[J].中国医学创新,2016,(2):111-114,4.基金项目
深圳市科技计划项目 （）
