摘要
Abstract
Objective:To observe the therapeutic effect of Nicorandil for the treatmnet of diastolic heart failure.Method:Seventy patients with diastolic heart failure admitted to Department of cardiology in our hospital from July 2012 to December 2014 were selected and divided into the control group and the treatment group according to the random number table method,35 cases in each group.The control group received routine treatment for diastolic heart failure,while the treatment group was given Nicorandil(5 mg per time,3 times a day for 12 weeks) on the basis of routine treatment.The therapeutic effect,early diastolic velocity of mitral valve(E),peak diastolic velocity of mitral valve(A),early diastolic velocity of mitral annulus(e´),E/A,E/e´,NT-proBNP and 6MWT between the two groups were observed and compared before and after 12 weeks’treatment,and the adverse drug reactions were monitored at the same time.Result:After 12 weeks’treatment,the marked effective rate and total effective rate of the treatment group were significantly higher than those of the control group, the differences were statistically significant(P<0.05).The E,e´,E/A and 6MWT of the two groups after treatment were significantly higher than before treatment,the A,E/e´ and NT-proBNP level of the two groups after treatment were significantly lower than before treatment,and the improvement levels of above indexes in the treatment group were significantly better than those in the control group,the differences were statistically significant(P<0.05 orP<0.01).There were no obvious adverse reactions in the two groups.Conclusion:Oral Nicorandil on the basis of conventional therapy can improve the clinical symptoms and cardiac function in patients with diastolic heart failure.关键词
尼可地尔/舒张性心力衰竭/N末端脑钠肽前体Key words
Nicorandil/Diastolic heart failure/N-terminal pro-brain natriuretic peptide
