摘要
Abstract
Objective To investigate the effect of antiviral therapy on the prognosis of patients with HBV re⁃lated hepatocellular carcinoma postoperative before and after operation. Methods Retrospective analysis of the patients with hepatocellular carcinoma in our hospital from June 2008 to June 2012 in the high load HBV as⁃sociated HCC patients, according to whether the patients were to carry out anti viral treatment divided into two groups: Patients with simple radical resection as control group (65 cases in group A), and patients who under⁃went radical resection combined with antiviral therapy were the experimental group (70 cases in group B). The two groups of patients with postoperative Child-Pugh score, DNA HBV copy number, liver reserve function, post⁃operative complications, postoperative tumour-free survival time differences were compared. Results In the control group and the experimental group, DNA HBV copy and Child-Pugh scores were having obvious statisti⁃cal difference (P<0.001) at different stages; At the same time, the experimental group and control group pa⁃tients with postoperative acute liver failure (P=0.0289), hepatic encephalopathy (P=0.0216), the incidence of liv⁃er and kidney syndrome (P=0.0411) were statistically significant differences; Postoperative tumour-free survival rate, the control group and the experimental group were 1 years, 2 years, 3 years of tumour-free survival rates were 80%, 36.9%, 13.8% and 92.9%, 64.3%, 31.4%, respectively. There was no significant statistical difference (P=0.2598) to compared with 1 years without tumor survival rate in experimental group and contril group;Howev⁃er, 2 years, 3 years of tumor free survival rate compared to have obvious statistical difference (P=0.0015, P=0.0153). Rank Log analysis can get 3 years overall disease-free survival rate has statistical significance differ⁃ence (P<0.001). Conclusion Radical resection of liver cancer combined with antiviral therapy can signifi⁃cantly reduce the incidence of postoperative complications, promote the recovery of liver function and prolong the survival period of patients without tumor.关键词
抗病毒治疗/肝细胞肝癌/根治性切除术/并发症Key words
Anti viral therapy/hepatocellular carci-noma/radical resection/complications分类
医药卫生
