中国中西医结合外科杂志Issue(1)：42-44,3.DOI:10.3969/j.issn.1007-6948.2016.01.012
应激对反流性食管炎模型大鼠食管下段pH值及黏膜血流的影响
The Influence of pH Values and Blood Flow of Lower Esophageal in Reflux Esophagitis Model Rat by Stress
摘要
Abstract
Objective To observe the influence of pH values and blood flow of lower esophageal in reflux Esophagitis model rat by stress, and to explore the effect of esophageal by psychological factor. Methods Pre⁃operative rats were randomly divided into 4 groups, control group, stress group, model group and stress plus mod⁃eling group, 15 rats in each group. Reflux Esophagitis rat model was established by the method of improved part cardiac muscle incision and part outlay-pyloric ligation. 7 days later, stress group and stress plus modeling group were induced by water immersion and immobilization. And then, the pH values of distal esophagus, the esophageal mucosal blood flow were compared. Results Compare with control group, the stress group lead to the pH values(3.21 ± 0.32)and the blood flow[(38.62 ± 6.11)BPU]down(P<0.01), the model group lead to the pH values(2.23 ± 0.27)and the blood flow[(30.16 ± 6.79)BPU]down(P<0.01); compare with model group, the stress plus model group lead to the pH values(2.01 ± 0.19)and the blood flow[(14.41 ± 7.04)BPU] down(P<0.01). Conclusion The stress could aggravate ischemia of esophageal mucosa and make pH values and the blood flow down.关键词
反流性食管炎/水浸束缚/黏膜血流/pH值/大鼠Key words
Reflux Esophagitis/water immersion and immobilization/esophageal mucosal blood flow/pH values/rat分类
生物科学引用本文复制引用
王瑞,唐艳萍,弓艳霞,刘思邈,康丽丽..应激对反流性食管炎模型大鼠食管下段pH值及黏膜血流的影响[J].中国中西医结合外科杂志,2016,(1):42-44,3.基金项目
天津市卫生局科技基金 （）
