中华耳科学杂志Issue(4)：729-733,5.DOI:10.3969/j.issn.1672-2922.2015.04.040
晚期糖基化终末产物受体与核因子-κβ在中耳胆脂瘤中的表达
Expression of receptors for advanced glycation end product (RAGE) and nuclear factor-κβ(NF-κβ) in middle ear cholesteatoma
摘要
Abstract
Objective To study the roles of NF-κβand RAGE in the pathogenesis of middle ear cholestea-toma. Methods Samples of middle ear cholesteatoma (n=23) and normal external ear canal skin (n=18) were collected during middle ear surgeries. Expression of NF-κβand RAGE was examined by immunohistochemis-try. Results All epithelial cells in cholesteatoma revealed abundant plasma expression of NF-κβand RAGE, significantly higher than that in normal skin (0.442±0.060 vs 0.293±0.047 and 0.175±0.017 vs 0.133±0.013, respectively;p<0.01). There was a weak correlation between NF-κβand RAGE expression in middle ear cho-lesteatoma epithelium tissues (r=0.546, p=0.034). Conclusion NF-κβand RAGE may be important factors in-volved in the occurrence and development of middle ear cholesteatom. The signal pathway of RAGE and NF-κβmay be a new drug target in non-surgical treatment of middle ear cholesteatoma.关键词
中耳胆脂瘤/核因子-κβ/晚期糖基化终末产物受体Key words
middle ear cholesteatoma/NF-κβ/RAGE分类
医药卫生引用本文复制引用
廖军,林昶..晚期糖基化终末产物受体与核因子-κβ在中耳胆脂瘤中的表达[J].中华耳科学杂志,2015,(4):729-733,5.基金项目
泉州市社会发展科技计划项目（2013Z60），并获泉州市卫生局资助。 （）
