中国现代中药Issue(1)：16-35,20.DOI:10.13313/j.issn.1673-4890.2016.1.004
人参化学成分的药物代谢动力学研究
Pharmacokinetic Studies of Chemical Constituents of Ginseng
摘要
Abstract
The wide range of therapeutic and health care potential of ginseng has been studied extensively,and ginsenosides,the principal active ingredients of ginseng,are shown to be involved in modulating multiple physiological activities.Biological and environmental factors may affect the efficacy of ginsenosides.Evidence from pharmacokinetic and metabolic studies of ginsenosides demonstrated that (1 )the absorption of many ginsenosides from gastrointestinal tract is different along with their different degrees of glycosylation in the molecular structure;(2)the poor membrane permeability of polyglycosylated prototypic ginsenoside predicted from the human Caco-2 cell monolayer model restricted their oral absorption badly;(3 )ginsenoside may be metabolized mainly to their prosaponins and /or aglycones by intestinal microflora before absorption into circulatory system;(4)the intestinal microflora-dependent biotransformation of some ginsenosides in the gastrointestinal tract could reflect a pathway of bioactivation resulting in the formation of bioactive intermediates and /or end-products,suggesting that ginsenoside is likely to be a prodrug;and (5)intact and some deglycosylated products are cleared from the body.This review provides an overview of the recent advances in biotransformation and /or metabolism as well as pharmacokinetics of ginsenosides,which might greatly contribute to supply the scientific basis for Evidence-Based Medicine in clarifying the effective substance basis of ginseng.关键词
人参/人参皂苷/药物代谢动力学Key words
Panax ginseng/ginsenoside/pharmacokinetic引用本文复制引用
杨秀伟..人参化学成分的药物代谢动力学研究[J].中国现代中药,2016,(1):16-35,20.基金项目
国家自然科学基金重点项目（81530097）；“十二五”国家科技支撑专项 （）
