北京中医药大学学报Issue(1)：16-20,5.DOI:10.3969/j.issn.1006-2157.2016.01.003
糖肾清2号方对2型糖尿病模型小鼠肾功能的影响∗
Protective effect of Tangshenqing Formula II on renal function of type 2 diabetic mice
摘要
Abstract
Objective To observe the protective effect of Tangshenqing Formula II ( TSQF) on the renal function of mice with type 2 diabetes mellitus ( DM) . Methods KK-Ay mice, a spontaneous DM mod-el, were fed with fat-enriched diet for three weeks. Based on their serum glucose ( Glu) and body weight ( BW) , the mice were divided into model group, valsartan group, high, middle, and low dose of TSQF ( high-, mid-, low- dose ) group ( n =6 each ) and were treated for consecutive 12 weeks. And six C57BL/6J mice were included into control group. At the timepoint of Week 0, 4, 8, 12, Glu, urine al-bumin ( Alb) , urine creatine ( Cr) , Alb/Cr( ACR) and 24-h urine protein ( pr/24 h) were detected. At the end of Week 12, all the mice were sacrificed and their serum samples were collected. And the serum levels of TG, TC, Scr, BUN and β2-MG were measured. Results Compared with the control group, <br> the levels of pr/24 h, ACR, Scr, TG and TC in the model group significantly increased ( P<0. 05 or P<0. 01), While BUN,β2-MG and ratio of kidney weight to body weight showed no statistcal differences (P>0. 05). Compared to the model group, the levels of Scr, TG and ACR in valsartan group and three TSQF groups significantly decreased (P<0. 05 or P<0. 01), and those of TC, Glu, and pr/24 h de-creased at different degree. Conclusion TSQF could reduce the serum levels of Glu, Scr and TG of kk-Ay mice, and alleviate the kidney injuries to reduce the progression of diabetic nephropathy.关键词
糖尿病肾病/肾功能/糖肾清2号方/小鼠Key words
diabetic nephropathy/renal function/Tangshenqing Formula II/mice分类
医药卫生引用本文复制引用
张继胜,沈志明,孟凤仙,商学征,白羽,王亚南,马卫国,刘慧,王康,陈祎,陆妍..糖肾清2号方对2型糖尿病模型小鼠肾功能的影响∗[J].北京中医药大学学报,2016,(1):16-20,5.基金项目
国家自然科学基金资助项目(No.81273886) （No.81273886）
