北京中医药大学学报Issue(1)：21-25,5.DOI:10.3969/j.issn.1006-2157.2016.01.004
蜘蛛香成分11-ethoxyviburtinal对肠易激综合征大鼠肠嗜铬细胞及肥大细胞表达的影响∗
Influences of 11-ethoxyviburtinal of Valeriana jatamansi Jones on the ex-pression of enterochromaffin cells and mast cells in rats with irritable bowel syndrome
摘要
Abstract
Objective To investigate the effects of 11-ethoxyviburtinal of Valeriana jatamansi Jones on the expression of enterochromaffin cells ( EC) and mast cells ( MC) in rats with irritable bowel syndrome ( IBS) . Methods The IBS rat model was induced by chronic unpredictable stress with isolation. Male SD rats were randomly divided into six groups:control group,model group, pinaverium group at the dose of 25 mg/kg,and high-, mid-and low-dose of 11-ethoxyviburtinal group at dose of 1. 2, 0. 6, and 0. 3 mg/kg respectively. The number of 5-HT positive immunoreactive colonic EC was detected by the method of immunohistochemistry and that of colonic MC was measured with toluidine blue staining. Results Compared with control group, the number of 5-HT positive immunoreactive colonic EC and MC increased significantly in model group ( P <0 . 05 ) . The high dose of 11-ethoxyviburtinal could significantly de-crease the number of colonic EC and MC ( P<0 . 05 ) . Conclusion The 11-ethoxyviburtinal of Valeri-ana jatamansi Jones could significantly reduce the number of 5-HT positive immunoreactive 5-HT positive immunoreactive EC and MC in colon tissue of rats with IBS.关键词
蜘蛛香/11-ethoxyviburtinal/肠易激综合征/肠嗜铬细胞/肥大细胞/大鼠Key words
Valeriana jatamansi Jones/11-ethoxyviburtinal/irritable bowel syndrome/enterochromaffin cell/mast cell/rats分类
医药卫生引用本文复制引用
肖丛瑞,陶丝雨,闫兴丽,高增平,史瑞瑞,王娟,王晶..蜘蛛香成分11-ethoxyviburtinal对肠易激综合征大鼠肠嗜铬细胞及肥大细胞表达的影响∗[J].北京中医药大学学报,2016,(1):21-25,5.基金项目
国家自然科学基金资助项目(No.81374044) （No.81374044）
