北京中医药大学学报Issue(1)：77-81,5.DOI:10.3969/j.issn.1006-2157.2016.01.015
健脾滋肾法对系统性红斑狼疮的疗效及患者生活质量的影响∗
Effects of spleen-fortifying and kidney-replenishing therapy on manifesta-tion and quality of life in patients with systemic lupus erythematosus dis-ease
摘要
Abstract
Objective To explore the effects of spleen-fortifying and kidney-replenishing therapy on man-ifestation and quality of life in patients with systemic lupus erythematosus disease ( SLE) . Methods 50 SLE patients were randomly divided into treatment group and control group. Both groups were given pred-nisone tablets combined with hydroxychloroquine sulfate while the treatment group also took the Spleen-fortifying and Kidney-replenishing Decoction ( Jianpi Yishen Tang ) . Changes of clinical manifestations and laboratory parameters before and after treatment were used to evaluate the efficacy and effects on the quality of life. Results Total effective rate of 88. 0% with 4 cases of clinical response, 10 cases of re-markable effect, 8 cases of effect and 3 cases of non-respond in the treatment group, was significantly higher than 72. 0% of the control group (clinical response 2 cases, remarkable effect 6 cases, effect 10 cases and non-response 7 cases) (P<0. 05). There was no significant difference between the two groups in SLEDAI scores. The treatment group was significantly superior to the control group (P<0. 01) in im-proving patients’ quality of life and scores of SDS and SAS. TCM symptom scores in the treatment group were significantly lower than those in the control group (P<0. 05). IgG, CRP and other laboratory pa-rameters in the treatment group were also significantly lower than that of the control group ( P<0 . 05 ) . Levels of IgM, C4, WBC, and RBC in the treatment group were significantly higher than those in the control group ( P<0 . 05 ) . Conclusion Spleen-fortifying and kidney-replenishing therapy could signifi-cantly attenuate clinical manifestations, disease activity, TCM symptom scores and relieve anxiety and depression in SLE patients. The efficiency and safety had been proved to improve the quality of patents’ life.关键词
健脾滋肾法/系统性红斑狼疮/临床疗效/生活质量Key words
spleen-fortifying and kidney-replenishing therapy/systemic lupus erythematosus/efficacy e-valuation/quality of life分类
医药卫生引用本文复制引用
杨小静,黄传兵,刘轶菲,杨秀丽,贾静云,武敏..健脾滋肾法对系统性红斑狼疮的疗效及患者生活质量的影响∗[J].北京中医药大学学报,2016,(1):77-81,5.基金项目
国家临床重点学科中医风湿病学建设项目(No.财社〔2013〕239号),国家中医药管理局重点学科资助项目(No.2011bXK003),安徽省科学技术厅科技计划资助项目(No.1306C083035) （No.财社〔2013〕239号）
