北京中医药大学学报Issue(2)：132-135,4.DOI:10.3969/j.issn.1006-2157.2016.02.009
补肾活血中药对原发性青光眼术后视神经保护作用的临床研究∗
Neuroprotective effects of kidney-tonifying and blood-activating medici-nals on optical nerve in glaucomatous eyes after filtering surgery
摘要
Abstract
Objective To observe the neuroprotective effects of kidney-tonifying and blood-activating me-dicinals on optical nerve in glaucomatous eyes after filtering surgery with intraocular pressure( IOP) under control. Methods A prospective study was conducted to enroll 36 cases of primary glaucoma after filte-ring surgery with IOP under control. The subjects were randomly divided into control group and treatment group. The control group received monitoring and IOP control management only while the treatment group was added oral intake of kidney-tonifying and blood-activating medicinals for three treatment courses ( each course lasts two months with a total of six months) . Visual acuity, IOP, visual field, optic nerve scanning, and VEP were evaluated before and after treatment. Results The visual acuity and IOP of two group showed no significant changes before and after treatment. After treatment,mean sensitivity ( MS) , mean defect ( MD) , loss variance ( LV) , average retinal nerve fiber layer thickness ( RNFL) , and pat-tern visual evoked potential ( LP100 , AP100 ) were significantly improved in the treatment group ( P <0. 05 ) . There was no significant change in C/D and RA in the treatment group after treatment ( P >0. 05 ) . There were no significant changes in all parameters in the control group after treatment ( P >0. 05). Compared with the control group, MS , MD, LV, average RNFL’s thickness, LP100, and AP100 of two groups were statistically significant after treatment ( P<0. 05 ) . Conclusion Kidney-tonifying and blood-activating medicinals could improve vision, VEP and RNFL thickness in primary glaucomatous eyes after filtering surgery thereby protecting the optic nerve and visual function in glaucomatous patients.关键词
青光眼/视神经保护/补肾活血/临床研究Key words
glaucoma/neuroprotection/kidney-tonifying and blood-activating medicinals/clinical re-search分类
医药卫生引用本文复制引用
汪伟,李妍,刘红佶,朱新萍,李翔..补肾活血中药对原发性青光眼术后视神经保护作用的临床研究∗[J].北京中医药大学学报,2016,(2):132-135,4.基金项目
国家自然科学基金资助项目(No.81373695) （No.81373695）
