北京中医药大学学报Issue(2)：144-150,7.DOI:10.3969/j.issn.1006-2157.2016.02.012
中医药降低早期糖尿病肾病患者蛋白尿水平疗效的Meta分析∗
Effects of Chinese medicine on proteinuria in patients with early diabetic nephropathy：a meta-analysis
摘要
Abstract
Objective To evaluate the effects of Traditional Chinese Medicine ( TCM) on proteinuria in patients with early diabetic nephropathy ( DN ) by using meta-analysis. Methods All publications of randomized controlled trials ( RCTs) studying traditional Chinese medicine in the treatment of early dia-betic nephropathy were searched and identified from Medline, PubMed, Cochrane Library, CBM, VIP and CNKI. The quality of included studies were evaluated by using revised Jadad scale. Rev. Man 5. 3 software was used for meta-analysis. Results A total of 27 RCTs involving 1 824 patients with early DN were included. Meta-analysis results showed that TCM treatment group could reduce the level of urine al-bumin excretion rate (UAER) and 24h urine albumin level with or without using angiotensin converting enzyme inhibitor and angiotensin receptor blocker ( ACEI/ARB) , when compared to control group using ACEI/ARB only. No serious adverse reactions were observed in TCM treatment groups. Conclusion It was proved that the efficiency and safety of traditional Chinese medicine on proteinuria in patients with early diabetic nephropathy.关键词
早期糖尿病肾病/中医药/Meta分析/血管紧张素转化酶抑制剂/血管紧张素Ⅱ受体拮抗剂/随机对照试验Key words
early diabetic nephropathy/traditional Chinese medicine/meta-analysis/ACEI/ARB/ran-domized controlled trials分类
医药卫生引用本文复制引用
代晓颖,张燕,易静,唐丽灵,何丽芳..中医药降低早期糖尿病肾病患者蛋白尿水平疗效的Meta分析∗[J].北京中医药大学学报,2016,(2):144-150,7.基金项目
世界卫生组织(WHO)“在初级卫生保健层面促进重庆市中医药服务研究”(No. WPCHN1408195) （WHO）
