长春中医药大学学报Issue(1)：22-24,3.DOI:10.13463/j.cnki.cczyy.2016.01.007
补肾健脾解毒利咽法对 IgA 肾病模型大鼠血清TNF-a、IL-6的影响
Bushenjianpi and Jieduliyan method to TNF-α,IL-6 of IgA nephropathy rat model
摘要
Abstract
Objective To study the effect and mechanism of Bushenjianpi and Jieduliyan method on IgA ne-phropathy. Methods The 72 Wistar rats were randomly divided into blank group,model group,Lotensin group,Bush-enjianpi and Jieduliyan high,medium and low dose group(is called traditional Chinese medicine high,medium and low dose group for short). The IgA nephropathy rat model were established by the method of feeding with bovine serum albumin(BSA)and injecting tail vein with lipopolysaccharide(LPS). Eight weeks administration later,each phase’s urine red blood cell count,UTP,TNF-αand IL-6 content were observed. Results Compared with model group,every groups’UTP decreased and traditional Chinese medicine dose group decreased extraordinary(P ﹤ 0. 05). Compared with model group,urine red blood cell count decreased significantly of every traditional Chinese medicine group(P ﹤0. 05),especially traditional Chinese medicine medium dose group improved significantly(P ﹤ 0. 01),but Lotensin group urine red blood cell count no drop(P ﹥ 0. 05). Compared with blank group,TNF-αIL-6 on model group’s in diabetic rats serum were significantly elevated(P ﹤ 0. 05). Compared with model group,TNF-α,IL-6 of treatment groups in diabetic rats serum decreased significantly(P ﹤ 0. 05),compared with every group,traditional Chinese medi-cine medium dose group’s data is the most significant(P ﹤ 0. 01). Conclusion Bushenjianpi and Jieduliyan method can reduce the model rats hematuria and proteinuria of IgA nephropathy,and reduce the content of IL-6 and TNF-αin serum which is better than Lotensin.关键词
补肾健脾/解毒利咽/IgA 肾病/模型大鼠/TNF-α/IL-6Key words
Bushenjianpi/Jieduliyan/IgA nephropathy/model rats/TNF-α/IL-6分类
医药卫生引用本文复制引用
王银萍,张冬梅,王宏安,张洪宝,张守琳..补肾健脾解毒利咽法对 IgA 肾病模型大鼠血清TNF-a、IL-6的影响[J].长春中医药大学学报,2016,(1):22-24,3.基金项目
吉林省科技厅自然科学基金项目（2015101214JC）；吉林省中医药管理局科技项目（2014-zd7）；吉林省教育厅“十二五”科学技术研究项目（2014第65号）。 （）
