Abstract
Objective To analyze the effect of Longxuejie powder in combined with mesalazine tablets enema in the treatment of ulcerative colitis(UC). Methods A total of 70 patients with UC who were admitted in our hospital from August,2014 to August,2015 were included in the study and randomized into the observation group and the con-trol group. The patients in the two groups were given corresponding adjustment of acid-base imbalance and water and electrolyte disturbance,and the improvement of nutritional status. The patients in the control group were orally given mesalazine tablets(1. 0 g),four times a day. On this basis,the patients in the observation group were given Longxuejie powder(1. 0 g),dissolving in 150mL normal saline for enema,retaining in the intestinal tract for 1h,once a day. The patients in the two groups were given a continuous 4-week treatment. The levels of IL-8,IL-10,TNF-α,HCT,fibrino-gen,and whole blood viscosity before and after treatment in the two groups were observed,and the efficacy was evalua-ted. Results After treatment,the levels of IL-8 and TNF-α were significantly reduced,while the IL-10 level was sig-nificantly elevated,moreover,the degree in the observation group was significantly superior to that in the control group (P ﹤ 0. 05). The decreased degree of the levels of HCT,fibrinogen,and whole blood viscosity after treatment in the observation group was significantly superior to that in the control group(P ﹤ 0. 05). The total effective rate in the ob-servation group(91. 4℅ )was significantly higher than that in the control group(71. 4℅ )(P ﹤ 0. 05). Conclusion Longxuejie powder in combined with mesalazine tablets enema in the treatment of UC can significantly reduce the in-flammatory reaction,improve the hypercoagulable state,enhance the therapeutic effect,and improve the patients’liv-ing qualities.Objective To analyze the effect of Longxuejie powder in combined with mesalazine tablets enema in the treatment of ulcerative colitis(UC). Methods A total of 70 patients with UC who were admitted in our hospital from August,2014 to August,2015 were included in the study and randomized into the observation group and the con-trol group. The patients in the two groups were given corresponding adjustment of acid-base imbalance and water and electrolyte disturbance,and the improvement of nutritional status. The patients in the control group were orally given mesalazine tablets(1. 0 g),four times a day. On this basis,the patients in the observation group were given Longxuejie powder(1. 0 g),dissolving in 150mL normal saline for enema,retaining in the intestinal tract for 1h,once a day. The patients in the two groups were given a continuous 4-week treatment. The levels of IL-8,IL-10,TNF-α,HCT,fibrino-gen,and whole blood viscosity before and after treatment in the two groups were observed,and the efficacy was evalua-ted. Results After treatment,the levels of IL-8 and TNF-α were significantly reduced,while the IL-10 level was sig-nificantly elevated,moreover,the degree in the observation group was significantly superior to that in the control group (P ﹤ 0. 05). The decreased degree of the levels of HCT,fibrinogen,and whole blood viscosity after treatment in the observation group was significantly superior to that in the control group(P ﹤ 0. 05). The total effective rate in the ob-servation group(91. 4℅ )was significantly higher than that in the control group(71. 4℅ )(P ﹤ 0. 05). Conclusion Longxuejie powder in combined with mesalazine tablets enema in the treatment of UC can significantly reduce the in-flammatory reaction,improve the hypercoagulable state,enhance the therapeutic effect,and improve the patients’liv-ing qualities.关键词
美沙拉嗪缓释片/血竭散/保留灌肠/溃疡性结肠炎Key words
mesalazine tablets/Longxuejie powder/enema/UC分类
医药卫生
