传感技术学报2016，Vol.29Issue(1)：9-14,6.DOI:10.3969/j.issn.1004-1699.2016.01.002
基于螺旋型铂铱合金电极的植入式葡萄糖生物传感器
The Implantable Glucose BiosensorBased on the Spiral-Type Pt-Ir Electrode
摘要
Abstract
A novel electrochemical sensor was fabricated by utilizing a spiral platinum-iridium alloy electrode to en-hance the loading of glucose oxidase on the implantable biosensor and increase the active area of the working elec-trode.The morphology of polyurethane(PU)semi-permeable membrane was observed by scanning electron micro-scope(SEM),and the performance of the sensor was investigated by cyclic voltammetry and chronoamperometry up-on the influence of the thickness and content of PU as well as the enzyme concentration. The result shows that the sensitivity of the as-prepared spiral sensor is 20 nA/(mmol/L)~30 nA/(mmol/L),which could be linearly detected the physiological glucose concentration between 2 mmol/L and 30 mmol/L. The sensors also showed good repeatability, stability and selectivity,which could be an ideal candidate of long-term implantable sensor to monitor the blood sug-ar for diabetes in the future.关键词
葡萄糖生物传感器/螺旋线圈电极/聚氨酯半透膜/选择性Key words
Glucose biosensor/Spiral-wired electrode/Polyurethane semi-permeable membrane/Selectivity分类
化学化工引用本文复制引用
余江渊,朱志刚,陈诚,李崭虹,陈云霞..基于螺旋型铂铱合金电极的植入式葡萄糖生物传感器[J].传感技术学报,2016,29(1):9-14,6.基金项目
上海高校特聘教授(东方学者)计划项目 （东方学者）
国家自然科学基金项目(61471233) （61471233）
上海市科委基础研究重点项目(13NM1401300) （13NM1401300）
上海市曙光计划项目(14SG52) （14SG52）
上海市人才基金项目(201346) （201346）
上海市科委扬帆计划项目(14YF1410600) （14YF1410600）
上海市教委晨光计划(13CG62) （13CG62）
