广东牙病防治2016，Vol.24Issue(2)：101-104,4.DOI:10.12016/j.issn.2096-1456.2016.02.008
纳米碳混悬液示踪早期舌鳞癌前哨淋巴结的临床研究
Clinical study on sentinel lymph node tracked by carbon nanoparticles on early tongue squamous cell carcinoma
摘要
Abstract
Objective To investigate the efficacy of carbon-nanoparticles suspension in detecting sentinel lymph nodes in cT1-2N0 oral tongue carcinoma and explore the application value of carbon-nanoparticles suspension in sentinel lymph node biopsy. Methods Fifty-eight patients with cT1-2N0 oral tongue carcinoma were enrolled in this prospective trial. Thirty patients received carbon nanoparticle injection around the tumor pre-operatively ( experimental group) , and the remaining 28 were injected with methylene blue dye ( control group) . All patients underwent elective neck dissection and routine pathological examination was performed in all resected specimens. Results The experimental group had a clear surgical field compared with the control group, and there is clear boundary between the staining lymph nodes and surrounding tissue. In the experimental group, the detection rate, sensitivity, accuracy rate, and false negative rate of the carbon-nanoparticles suspension were 96. 7% ( 29/30) , 87. 5% ( 7/8) , 93. 3% ( 28/30) , and 12. 5% ( 1/8) , respec-tively compared with 92. 8% ( 26/28) , 66. 7% ( 4/6) , 85. 7% ( 24/28) , and 33. 3% ( 2/6) , respectively, of the con-trol group. There is no significant difference in both groups ( P>0. 05) . Conclusion The application of carbon-nanop-articles suspension facilitate sentinel lymph node detection and histological evaluation and therefore, could be an impor-tant adjunct to sentinel lymph node biopsy in oral tongue squamous cell carcinoma.关键词
舌癌/癌,鳞状细胞/前哨淋巴结/示踪/纳米碳混悬液Key words
Tongue carcinoma/Squamous cell/carcinoma/Sentinel lymph nodes/Track/Carbon-nanoparti-cles suspension分类
医药卫生引用本文复制引用
钟江龙,范松,陈伟良,李群星,王友元,张大明..纳米碳混悬液示踪早期舌鳞癌前哨淋巴结的临床研究[J].广东牙病防治,2016,24(2):101-104,4.基金项目
国家自然科学基金(81172563/H1625) （81172563/H1625）
