河北医学2016，Vol.22Issue(2)：190-192,3.DOI:10.3969/j.issn.1006-6233.2016.02.005
灵芝多糖的抑瘤作用及对小鼠免疫系统影响的实验研究
Tumor Suppression Function and the Effect of Ganoderma Lucidum Polysaccharide on the Immune System of Mice
摘要
Abstract
Objective:To explore the inhibition of ganoderma polysaccharides and its effects on the im-mune system of mice. Method:95 mice were randomly selected and established the animal model of immu-nosuppression by tumor cell, then randomly divided into experimental group ( 48 cases) and control group ( 47 cases) . The mice in the experimental group were given ganoderma lucidum polysaccharide by oral liquid infusion, while the mice in the control group were given saline infusion, then the inluemce of ganoderma lu-cidum polysaccharides on mice survival time, tumor suppression effect and the immune system were observed and analyzed. Result:The survival period of the experimental mice in the experimental group was obviously higher than that of the control group ( P <0.05) , and serum TNF alpha, IL-2 levels of mice in the experi-mental group increased significantly, the tumor cells, NK activity and lymphocyte proliferation rate was also significantly higher than that of control group ( P < 0.05) . Conclusion:Ganoderma lucidum polysaccharide has no direct inhibitory effect on tumor in mice and its anti-tumor effect is mainly mediated by the immune system, and ganoderma lucidum polysaccharides can effectively prolong thesurvival. time.关键词
灵芝多糖/抑瘤作用/免疫系统/小鼠肿瘤Key words
Ganoderma lucidum polysaccharide/Tumor suppression effect/The immune system/Tumors in mice引用本文复制引用
卢玉振,李祥,周磊..灵芝多糖的抑瘤作用及对小鼠免疫系统影响的实验研究[J].河北医学,2016,22(2):190-192,3.基金项目
江苏省卫生厅科研基金项目,(编号:H201346) （编号:H201346）
