河北医学2016，Vol.22Issue(2)：209-212,4.DOI:10.3969/j.issn.1006-6233.2016.02.012
吸入糖皮质激素治疗稳定期COPD的疗效及对患者内皮功能及生活质量的影响
Effect of Inhaled Corticosteroids on the Pulmonary Function and Quality of Life in Patients with COPD in Stable Period
摘要
Abstract
Objective:To explore the clinical effect of inhaled corticosteroid ( ICS ) on the nitric oxide ( NO ) , pulmonary function and quality of life in patients with chronic obstructive pulmonary disease ( COPD) . Method:From January 2014 to January 2015, 40 cases hospitalized for COPD with high NO ex-haled volume were selected and divided into study group and control group, 20 cases in each group. The con-trol group was treated with routine treatment, while the study group was treated with inhaled glucocorticoid on the basis of routine treatment. After a week of treatment, the pulmonary function of the patients, second forced expiratory volume (FEV1), forced expiratory volume in 1 second (FEV1/FVC), Endothelial func-tion were observed. Result:The pulmonary function of the two groups was improved, and the improvement of FEV1/FVC and FEV1 in the study group were significantly better than those in the control group, and the difference was statistically significant ( P<0.05);After treatment, IMT, VS, VD, RI, and serum ET-1, sI-cam 1 of the control group had no obvious difference compared with those before treatment (P > 0.05), while IMT, RI and serum ET - 1, sI-cam 1 in the study group reduced, VS, VD was higher than before treatment, the difference was statistically significant (P < 0.05); After treatment, the exhaled serum NO breath and quality of life scores in the control group had no obvious difference compared with those before treatment ( P>0.05) , while breath NO, quality of life scores in the study group reduced, the difference was statistically significant (P< 0.05).Conclusion: Inhaled corticosteroids can improve the pulmonary function of patients with COPD, reduce the NO level of exhaled breath, improve the endothelial function and the quality of life.关键词
慢性阻塞性肺病/吸入糖皮质激素/一氧化氮/肺功能/生活质量Key words
Chronic obstructive pulmonary disease/Inhaled corticosteroid/Nitric oxide/Pul-monary function/Quality of life引用本文复制引用
赵洪达,陈建波,许群,江莲..吸入糖皮质激素治疗稳定期COPD的疗效及对患者内皮功能及生活质量的影响[J].河北医学,2016,22(2):209-212,4.基金项目
江苏省卫生厅重点学科省内开放课题,(编号:KF201207) （编号:KF201207）
