赵广生 1任志忠 2刘影 3周军 3张跃伟 3张明3
作者信息
- 1. 西安交通大学医学院第一附属医院 影像科，西安710000
- 2. 大连大学附属中山医院 介入治疗科，辽宁 大连 116001
- 3. 大连大学附属中山医院 介入治疗科，辽宁 大连 116001
- 折叠
摘要
Abstract
Objective ToevaluatetheeffectoflivecombinedBacillussubtilisandEnterococcusfaeciumenteric-coatedcapsulesinthepre-ventionandtreatmentofadverseeventsandcomplicationsaftertranscatheterarterialchemoembolization(TACE).Methods Atotalof239 patients who were diagnosed with hepatocellular carcinoma and treated with TACE from January 2012 to December 2013 were randomly divided into experimental group (n=111)and control group (n=128).The patients in the experimental group were orally given live combined Bacil-lus subtilis and Enterococcus faecium enteric-coated capsules 3 days before surgery,and the patients in the control group were given placebo with the same appearance.The adverse events,incidence of complications,and blood ammonia level after TACE were compared between the two groups.Independent-samples t-test was performed for comparison of continuous data between the two groups,and chi-square test was performedforcomparisonofcategoricaldata.Results Comparedwiththoseinthecontrolgroup,thepatientsintheexperimentalgrouphada significantly lower incidence of adverse events such as pyrexia,abdominal distension,and constipation (t=2.728,2.561,and 2.026,respec-tively;all P<0.05);meanwhile,the patients in the experimental group had a significantly lower incidence of postoperative complications such as liver abscess,ileus,spontaneous bacterial peritonitis,and hepatic encephalopathy than those in the control group (t =1.969,2.312, 2.987,and 2.826,respectively;all P<0.05).After treatment,the patients in the experimental group had a significantly lower blood ammo-nialevelcomparedwiththoseinthecontrolgroup(t=1.97;P<0.05).Conclusion Asanewkindoflivebacterialpreparation,Bacillus subtilis and Enterococcus faecium enteric-coated capsules can reduce abdominal discomfort and blood ammonia level after TACE,as well as the incidence of severe complications including liver abscesses,but related mechanisms need further studies.关键词
癌,肝细胞/化学栓塞,治疗性/枯草杆菌二联活菌肠溶胶囊/治疗结果Key words
carcinoma,hepatocellular/chemoembolization,therapeutic/bacillus subtilis and enterococcus faecium enteric -coated cap-sules/treatment outcome分类
医药卫生
