摘要
Abstract
Objective Toinvestigatetheclinicaleffectofsystemicchemotherapycombinedwithtranscatheterarterialchemoembolization (TACE)inthetreatmentofbreastcancerwithlivermetastases.Methods Atotalof86femalebreastcancerpatientswithlivermetastases who were treated in the Affiliated Hospital of Shandong Academy of Medical Sciences from December 2012 to December 2014 were selected and equally divided into experimental group and control group.The patients in the control group received systemic chemotherapy,and those in the experimental group received systemic chemotherapy combined with TACE.The clinical effect,changes in lesions,and patients′quali-ty of life (QOL)scores after treatment were compared between two groups.The t-test was applied for comparison of continuous data be-tweenthetwogroups,andthechi-squaretestwasappliedforcomparisonofcategoricaldatabetweenthetwogroups.Results Theexperi-mental group had a significantly higher overall response rate than the control group (90.70%vs 58.14%,χ2 =13.07,P=0.001).Com-pared with the control group,the experimental group had significantly smaller diameters of tumors and lymph nodes after treatment (t=4.26 and 4.63,both P<0.001),as well as significantly higher QOL scores at 3 and 6 months after treatment (t=6.30 and 3.89,both P<0.001).Conclusion SystemicchemotherapycombinedwithTACEhasasignificanttherapeuticeffectinbreastcancerpatientswithliver metastases,and can improve patients′symptoms,reduce adverse drug reactions,and improve QOL.As a safe and reliable therapeutic meth-od,it is worthy of clinical application.关键词
乳腺肿瘤/肿瘤转移/药物疗法/化学栓塞,治疗性Key words
breast neoplasms/neoplasm metastasis/drug therapy/chemoembolization,therapeutic分类
医药卫生
