临床肝胆病杂志Issue(1)：101-105,5.DOI:10.3969/j.issn.1001-5256.2016.01.018
磁共振扩散加权成像对经皮酒精注射术治疗兔VX2肝移植瘤后残余肿瘤微血管生成情况的评价
Diffusion-weighted magnetic resonance imaging for evaluation of micro-angiogenesis in residual tumor after treat-ment with percutaneous ethanol injection in a rabbit VX2 liver tumor model
摘要
Abstract
Objective Toinvestigatetheapplicationofdiffusion-weightedmagneticresonanceimaging(DW-MRI)fortheevaluationof the therapeutic effect of percutaneous ethanol injection (PEI)and its effect on micro-angiogenesis in residual tumor in a rabbit VX2 liver tumormodel.Methods Atotalof26rabbitswithVX2livertumorwererandomlydividedintoexperimentalgroupandcontrolgroup,with 13 rabbits in each group.CT-guided PEI was performed for the experimental group,and no treatment was performed for the control group. DW-MRI was performed at 1 week after operation.Apparent diffusion coefficient (ADC)ADCtotal in the active tumor areas and necrosis ar-eas were compared within the experimental group,ADCperf and microvascular density (MVD)count in the active tumor areas were compared between the two groups,and the correlation between ADCperf and MVD count was analyzed.The Shapiro-Wilk test was applied for normali-ty analysis,the Wilcoxon rank sum test was applied for comparison of continuous data between the two groups,and the correlation between ADCperfandMVDcountwasanalyzedbythePearsoncorrelationcoefficient.Results Intheexperimentalgroup,ADCtotalshowedasignifi-cant difference between the necrosis areas and the active tumor areas ([1.674 (1.340 -2.571)]×10 -3 mm2/s vs [1.296(1.120 -1.972)]×10 -3 mm2/s;Z=2.052,P=0.040).ADCperf and MDV count in the active tumor areas showed no significant differences be-tween the experimental group and the control group [0.568(0.381 -1.873)]×10-3 mm2/s vs [0.947(0.518-1.476)]×10-3 mm2/s,Z=0.487,P=0.626;23.641 ±6.138 vs 23.487 ±3.466;Z=-0.128,P=0.898).In both groups,ADCperf in the active tumor areas was posi-tivelycorrelatedwithMDVcount(r=0.583and0.593,P=0.037and0.033).Conclusion DW-MRIcanaccuratelyassessthethera-peutic effect of PEI and reflect the condition of micro-angiogenesis in a rabbit VX2 liver tumor model.At 1 week after PEI,PEI has no ob-vious effect on micro-angiogenesis in residual tumor.关键词
肝肿瘤/磁共振成像,弥散/导管消融术/模型,动物Key words
liver neoplasms/diffusion magnetic resonance imaging/catheter ablation/models,animal分类
医药卫生引用本文复制引用
陈娟,尹化斌,张欢欢,魏春晓,王丽,钱亭..磁共振扩散加权成像对经皮酒精注射术治疗兔VX2肝移植瘤后残余肿瘤微血管生成情况的评价[J].临床肝胆病杂志,2016,(1):101-105,5.基金项目
上海市闵行区科委课题 （）
