临床肝胆病杂志Issue(1)：106-109,4.DOI:10.3969/j.issn.1001-5256.2016.01.019
慢性乙型肝炎患者血小板指数与肝组织病理的关系
Correlation between platelet indices and liver pathological staging:an analysis of 167 patients with chronic hepatitis B
摘要
Abstract
Objective Toinvestigatethevaluesofaspartateaminotransferasetoplateletratioindex(APRI)andalanineaminotransferaseto platelet ratio index (BPRI)for the prediction of pathological changes in liver tissue in patients with chronic hepatitis B (CHB).Methods Atotalof167CHBpatientswhovisitedthePeople′sHospitalofLiuzhoufromFebruary2004toFebruary2014werecollected.Liverbiopsy, routine blood test,and liver function test were performed,and then the correlation between APRI/BPRI and liver pathology was analyzed. The Mann-Whitney U test was applied for comparison of continuous data between groups,and the receiver operating characteristic (ROC) curvewasusedtoevaluatethepredictivevaluesofAPRIandBPRIforliverpathologicalstaging.Results APRIwascomparedbetweenG0, G1,G2,G3,and G4 groups with different liver inflammation grades,and the G1 group had a significantly different APRI value than the G2 and G3 groups (both P<0.05);the G0-1 group had a significantly different APRI value than the G2-4 group (P<0.05).BPRI was al-so compared between these groups,and it differed significantly between the G0 group and G4 group and between the G1 group and G2 group (both P<0.05);the G0-1 group had a significantly different BPRI value than the G2-4 group (P<0.05).APRI and BPRI were com-pared between each two of S0,S1,S2,S3,and S4 groups,and they showed significant differences between the S2 and S3 groups (P<0.05).The areas under the ROC curve of APRI and BPRI for predicting liver inflammation G2 -4 were 0.748 and 0.736,respectively (95%CI:0.669-0.827 and 0.653-0.819,respectively;both P<0.000 1);the optimal cut-off values for APRI and BPRI to predict liver inflammation G2-4 were 0.601 and 0.630,respectively,with sensitivity,specificity,and Youden index of 63.6%/82.7%,74.5%/59.6%,and39.0%/42.4%,respectively.Conclusion APRIandBPRIcanbeusedtopredictliverinflammatoryactivityinCHBpatients.关键词
肝炎,乙型,慢性/血小板计数/病理学Key words
hepatitis B,chronic/platelet count/pathology分类
医药卫生引用本文复制引用
陈念,黄卫娥,苏明华,江建宁..慢性乙型肝炎患者血小板指数与肝组织病理的关系[J].临床肝胆病杂志,2016,(1):106-109,4.基金项目
广西自然科学青年基金资助项目（0832037）；广西自然科学基金（0832117）；广西卫生厅自筹课题（z2014410）；柳州市人民医院院内课题 （）
