临床肝胆病杂志Issue(1)：185-187,3.DOI:10.3969/j.issn.1001-5256.2016.01.041
成簇的规律间隔短回文重复序列/Cas9系统在病毒领域的应用
Application of CRISPR/Cas9 system in virus research
摘要
Abstract
To date,the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has been widely used to edit the genome in many species and cells.The system is the third generation of artificial endonuclease,which can edit DNA by recognizing short DNA sequences.This paper reviews the structural features of the system and its application in virus research,such as the functional studies of virus-related genes and the exploration of antiviral therapies (including HIV,HBV,and EB virus),looking forward to the future direc-tion of virus research.关键词
病毒/RN A编辑/综述Key words
virus/RNA editing/review分类
医药卫生引用本文复制引用
郑庆芬,段钟平,李建生..成簇的规律间隔短回文重复序列/Cas9系统在病毒领域的应用[J].临床肝胆病杂志,2016,(1):185-187,3.基金项目
科研基地建设－重大传染病防治协同创新中心（2011协同创新中心）（115215）；“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项基金资助项目（2013ZX10002002－006）；北京市科学技术委员会资助临床特色项目 （）
