临床神经外科杂志2016，Vol.13Issue(1)：49-55,59,8.DOI:10.3969/j.issn.1672-7770.2016.01.013
神经外科重症监护病房细菌流行及耐药性的 20 年监测
Distribution and antimicrobial-resistance of bacteria isolated in nosocomial infection in NSICU within 20 years
摘要
Abstract
Objective To investigate the prevalence and antibiotic-resistance of pathogenic bacteria in nosocomial infection in the neurosurgical intensive care unit ( NSICU ) .Method The data of pathogenic bacteria isolated was recorded from NSICU of Beijing Tiantan Hospital , during January of 1995 to November 2014 .Epidemiology and antimicrobial-resistance of pathogenic bacteria were analyzed retrospectively .And infections in NSICU were in contrasted with intracranial infection in epidemiology of bacteria and antimicrobial-resisitance during January to November of 2014 . Results From the sites of infection , sputum account for 91 .57%, cerebrospinal fluid ( CSF ) 3 .85%and Others 4 .58%.Among all bacteria isolates ( n=5409 ) , Gram-negative cocci was 3987 isolates,and Gram-positive 1422 isolates, respectively.The most frequently isolated bacteria was Pseudomonas aeruginosa , which was 1340 isolates.Followed by Acinetobacter baumannii 1330 isolates, Staphylococcus aureusn 1122 isolate, Klebsiella pneumoniae 588 isolates, Coagulase-negative staphylococci 209 isolates.While Gram-negative was separated 66 isolates, and Gram-positive 60 isolates from intracranial infection from January of 2007 to November of 2014 . Acinetobacter and Pseudomonas aeruginosa occupied a large part in G -and were almost resistance to all common antibiotics , yet Acinetobacter in CSF was sensitive to ceftizoxime and sulfonamides . While Staphylococcus in G + was in high susceptibility to vancomycin .Conclutions Pulmonary infection caused by the G -was the main infection in NSICU .Pathogenic bacteria are mainly gram-negative bacterium , multi-drug resistance of acinetobacter and pseudomonas aeruginosa significantly increased .Gram-negative and Gram-positive that were separated from CSF in NICU had no difference,whatever their resistance rates to antibiotic was in accordance with that from NICU . However Acinetobacter in CSF was sensitive to ceftizoxime and sulfonamides .关键词
细菌感染/神经外科重症监护病房/抗菌药物/耐药性Key words
bacterial infection/neurosurgical intensive care unit/antibiotic/antibiotic resist-ance分类
医药卫生引用本文复制引用
李倩,武元星,唐明忠,王强..神经外科重症监护病房细菌流行及耐药性的 20 年监测[J].临床神经外科杂志,2016,13(1):49-55,59,8.基金项目
首都医科大学基础与临床联合项目(13JL24) （13JL24）
