日用化学工业Issue(2)：92-96,5.DOI:10.13218/j.cnki.csdc.2016.02.007
橙皮素胶束溶液的制备及透明质酸对其稳定性和经皮渗透作用的影响
Preparation of hesperetin micelle pseudo solution and influence of hyaluronic acid on its stability and percutaneous osmosis action
摘要
Abstract
Pseudo solution of hesperetin micelle was prepared,and influence of hyaluronic acid on its stability and percutaneous osmosis activity was investigated using Zeta potential and percutaneous osmosis rate as the respective indices. Experimental results showed that hyaluronic acid can significantly enhance the stability and percutaneous osmosis activity of hesperetin micelle pseudo solution. When the mass fraction of hyaluronic acid achieves 0. 5%,the micelle pseudo solution becomes transparent,stable and without unpleasant odor. Under room temperature condition,its average pH value is 5. 4 ± 0. 1 and average Zeta potential is - 32. 62 mV. The steady osmosis rate constant Js of hesperetin through cavy skin achieves 7. 475 8 μg /(cm2 ·h),which is 1. 5 multiples as compared with that of the control group. The micelle pseudo solution shows good stability in cold resistance test and heat resistance test.关键词
护肤化妆品添加剂/橙皮素/胶束/透明质酸/稳定性/经皮渗透活性Key words
skin care cosmetic additives/hesperetin/micelle/hyaluronic acid/stability/percutaneous osmosis activity引用本文复制引用
张晓宇,侯彩平,赵丽萍,谢茵,刘丽清,何亚丽,田青平..橙皮素胶束溶液的制备及透明质酸对其稳定性和经皮渗透作用的影响[J].日用化学工业,2016,(2):92-96,5.基金项目
山西省科技攻关项目 （）
