山东医药Issue(1)：15-17,3.DOI:10.3969/j.issn.1002-266X.2016.01.005
乳腺癌组织中 Cbl-b 和 Itch 蛋白的表达变化及意义
Expression changes of Cbl-b and Itch in breast carcinoma and the clinical significance
摘要
Abstract
Objective To investigate the expression changes of Cbl-b and Itch in the breast carcinoma tissues and the clinical significance.Methods The expression of Cbl-b and Itch in 116 specimens of breast carcinoma and 30 specimens of normal breast tissues was detected by immunohistochemistry.Meanwhile, we also statistically analyzed its relationship with the clinical and pathological factors.Results The positive expression rates of Cbl-b and Itch in the breast carcinoma tissues were respectively 78.45%(91/116) and 58.62%(68/116).The positive expression rates of Cbl-b and Itch in the normal tisseus were 26.67%(8/30) and 23.33%(7/30).The positive expression rates of Cbl-b and Itch in the breast cancer tissues were higher than those of the normal tissues (all P<0.01).The positive expression of Cbl-b and Itch was positively correlated with depth of invasion, lymph node metastasis and TNM staging (r=0.172,P=0.014;r=0.119, P=0.022;r=0.117,P=0.017;r=0.145,P=0.028; r=0.134,P=0.027; r=0.138,P=0.025).The positive ex-pression of Cbl-b and Itch was not related with age of patient and the lesion size (all P>0.05).Conclusion The expres-sion of Cbl-b and Itch is increased in the breast cancer tissues, and both of them take part in the progress of breast carcino-ma.关键词
乳腺肿瘤/Cbl-b蛋白/Itch蛋白Key words
breast neoplasms/Cbl-b protein/Itch protein分类
医药卫生引用本文复制引用
韩明强,李建辉,闫静波,刘澄湘,崔占斌..乳腺癌组织中 Cbl-b 和 Itch 蛋白的表达变化及意义[J].山东医药,2016,(1):15-17,3.基金项目
河北省卫生和计划生育委员会2015年度医学科学研究重点课题（20150176）。 （）
