摘要
Abstract
Objective:To confirm the protective effects of salidroside on cerebral ischemia/reperfusion (I/R) injury and explore its molecular mechanism .Methods :SD rats were randomly divided into four groups:normal control ,normal rats+salidroside ,I/R group ,I/R +salidroside .Rats in groups with salidroside treatment were giv‐en salidroside (40 mg/kg) for two weeks .I/R rats were treated by the thread ligation in internal carotid artery .In the end of treatment ,the brain of each rat was collected .The infarct sizes ,the levels of malondialdehyde (MDA) and 8‐dydroxy‐2’‐deoxyguanosine (8‐O HdG ) in brain tissues ,and the expression of HIF‐1a , lactate dehydrogenase (LDH) and hexokinase (HK) were observed .Results :Salidroside treatment of normal rats induced a significant in‐crease in the expression of HIF‐1a ,LDH ,HK as compared to normal control .I/R resulted in the increase in the ex‐pression of HIF‐1a ,LDH ,HK as compared to normal control .Rats in I/R+ salidroside group had a significantly weakened increase in expression of HIF‐1a ,LDH ,HK as compared to I/R group .Infarct sizes were significantly smaller and levels of MAP and 8‐OHdG were significantly lower in I/R+salidroside group than those in I/R group . Conclusion :Salidroside induces cerebral HIF‐1a expression and increase enzyme levels for glucolysis ,which showed protective effects against cerebral ischemia reperfusion injury .关键词
脑/再灌注损伤/红景天苷/缺氧诱导因子1 乳酸脱氢酶类/己糖激酶Key words
Brain/Reperfusion injury/Rhodioloside/Hypoxia-tnducible factor 1/Lactate dehydrogen-ases/Hexokinase分类
医药卫生
